Genes associated with alternatively activated macrophages discretely regulate helminth infection and pathogenesis in experimental mouse models

Immunobiology ◽  
2010 ◽  
Vol 215 (9-10) ◽  
pp. 704-708 ◽  
Author(s):  
William G.C. Horsnell ◽  
Frank Brombacher
Keyword(s):  
Mouse Models ◽  
Helminth Infection ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Experimental Mouse ◽  
Alternatively Activated

scholarly journals Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes

2010 ◽  
Vol 2010 ◽  
pp. 1-14 ◽  
Author(s):  
Stephen J. Jenkins ◽  
Judith E. Allen
Keyword(s):  
Macrophage Activation ◽  
Helminth Infection ◽  
Current Knowledge ◽  
Host Tissue ◽  
Macrophage Phenotype ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Helminth Infections ◽  
Host Metabolism ◽  
Alternatively Activated

This review summarizes current knowledge of macrophages in helminth infections, with a focus not only on delineating the striking similarities in macrophage phenotype between diverse infections but also on highlighting the differences. Findings from many different labs illustrate that macrophages in helminth infection can act as anti-parasite effectors but can also act as powerful immune suppressors. The specific role for their alternative (Th2-mediated) activation in helminth killing or expulsion versus immune regulation remains to be determined. Meanwhile, the rapid growth in knowledge of alternatively activated macrophages will require an even more expansive view of their potential functions to include repair of host tissue and regulation of host metabolism.

scholarly journals Alternatively Activated Macrophages in Intestinal Helminth Infection: Effects on Concurrent Bacterial Colitis

2007 ◽  
Vol 179 (7) ◽  
pp. 4721-4731 ◽  
Author(s):  
Meiqian Weng ◽  
Deke Huntley ◽  
I-Fei Huang ◽  
Ondulla Foye-Jackson ◽  
Lijian Wang ◽  
...  
Keyword(s):  
Helminth Infection ◽  
Intestinal Helminth ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

Alternatively activated macrophages in intestinal helminth infection

2007 ◽  
Vol 13 (supplement) ◽  
pp. 644
Author(s):  
M Weng ◽  
D Huntley ◽  
O Foye-Jackson ◽  
J Wang ◽  
W Walker ◽  
...  
Keyword(s):  
Helminth Infection ◽  
Intestinal Helminth ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

scholarly journals Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

2009 ◽  
Vol 182 (5) ◽  
pp. 3084-3094 ◽  
Author(s):  
Katie J. Mylonas ◽  
Meera G. Nair ◽  
Lidia Prieto-Lafuente ◽  
Daniel Paape ◽  
Judith E. Allen
Keyword(s):  
Helminth Infection ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

scholarly journals Th2 Immune Responses and Alternatively Activated Macrophages (AAMacs) in Helminth Infection in Aged Mice

2011 ◽  
Vol 73 (4) ◽  
pp. 511-516 ◽  
Author(s):  
Yasuhiro SUGAWARA ◽  
Noritsugu AZUMA ◽  
Sachi ONODERA ◽  
Yuichi TSUNOKA ◽  
Motoko MORIMOTO
Keyword(s):  
Immune Responses ◽  
Helminth Infection ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Aged Mice ◽  
Alternatively Activated
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