Drug interaction profile of TKI alectinib allows effective and safe treatment of ALK+ lung cancer in the kidney transplant recipient

2021 ◽  
Vol 99 ◽  
pp. 108012
Author(s):  
Ondrej Bilek ◽  
Milos Holanek ◽  
Jan Jurica ◽  
Sona Stepankova ◽  
Jiri Vasina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Interaction ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Safe Treatment

scholarly journals Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Joanna C. Masters ◽  
Mita M. Shah ◽  
Ashley A. Feist
Keyword(s):  
Drug Interaction ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Immunosuppressive Agent ◽  
Therapeutic Window ◽  
Blood Levels ◽  
Kidney Transplant Patient ◽  
Close Monitoring ◽  
Subsequent Increase

Purpose. The case of a kidney transplant recipient who experienced a probable drug interaction between sirolimus and ranolazine is reported.Summary. The narrow therapeutic window of immunosuppressive therapy in transplant recipients requires close monitoring for potential drug-drug interactions. The patient, a 57-year-old Caucasian male kidney transplant recipient, was stable for years on sirolimus as his primary immunosuppressive agent and had a history of chronic angina, for which he was prescribed ranolazine. Upon addition and dose escalation of ranolazine, whole blood sirolimus levels more than tripled, rising to immeasurably high concentrations. After holding sirolimus on multiple occasions and reducing dosage more than 50%, blood levels returned to therapeutic range, while continuing ranolazine.Conclusion. Since ranolazine is a documented P-GP and CYP3A inhibitor, and sirolimus a known substrate for both pathways, it is proposed that ranolazine inhibition of P-GP and CYP3A4 contributed to the significant elevation in sirolimus exposure. No alternative causes for the rise in sirolimus exposure were found, and assessment with the Drug Interaction Probability Scale finds this interaction to be probable. Clinicians should be aware of the potential for this interaction to cause elevated sirolimus exposure and subsequent increase in clinical effect or toxicity, in this case overimmunosuppression.

Diabetes mellitus development secondary to chronic pancreatitis in a kidney transplant recipient

2018 ◽  
Author(s):  
Alparslan Ersoy ◽  
Nimet Aktas ◽  
Aysegul Oruc ◽  
Abdulmecit Yildiz ◽  
Canan Ersoy
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient

scholarly journals POS-210 POST-MORTEM MOLECULAR INVESTIGATIONS OF SARS-COV-2 IN AN UNEXPECTED DEATH OF A RECENT KIDNEY TRANSPLANT RECIPIENT

2021 ◽  
Vol 6 (4) ◽  
pp. S88
Author(s):  
E.L. SIMMS ◽  
H. Chung ◽  
L. Oberding ◽  
D. Muruve ◽  
B. McDonald ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Post Mortem ◽  
Unexpected Death

scholarly journals Multiple papules on the face in a kidney transplant recipient

2020 ◽  
Vol 21 (1) ◽  
pp. 428-430
Author(s):  
Jin Sasaki ◽  
Satoru Shinkuma ◽  
Riichiro Abe
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
The Face

scholarly journals Modified combined radiotherapy for cervical cancer in kidney transplant recipient

2021 ◽  
Author(s):  
Olga Matylevich ◽  
Aleksander Shushkevich ◽  
Valentina Suslova ◽  
Pavel Perevoschikov ◽  
Siarhei Mavrichev
Keyword(s):  
Cervical Cancer ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient

scholarly journals Reinfection with SARS‐CoV‐2 in a kidney transplant recipient

2021 ◽  
Author(s):  
Shirkhan Amikishiyev ◽  
Erol Demir ◽  
Sarvan Aghamuradov ◽  
Nurana Garayeva ◽  
Ayse Serra Artan ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient
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