Effect of sequential applications of topical tacrolimus and topical corticosteroids in the treatment of pediatric atopic dermatitis: An open-label pilot study

2009 ◽  
Vol 60 (2) ◽  
pp. 212-217 ◽  
Author(s):  
Yasuo Kubota ◽  
Kozo Yoneda ◽  
Kozo Nakai ◽  
Junko Katsuura ◽  
Tetsuya Moriue ◽  
...  
2012 ◽  
Vol 67 (4) ◽  
pp. 636-641 ◽  
Author(s):  
Terrence Colin Keaney ◽  
Tina Bhutani ◽  
Priya Sivanesan ◽  
Grace D. Bandow ◽  
Sari Beth Weinstein ◽  
...  

2018 ◽  
Vol 21 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Sanford Singer ◽  
Jamie Koenekoop ◽  
Jonathan Meddings ◽  
Julie Powell ◽  
Anne Desroches ◽  
...  

2004 ◽  
Vol 8 (4) ◽  
pp. 213-219 ◽  
Author(s):  
Jerry Tan ◽  
Richard Langley

Background: Most previously published trials of topical tacrolimus in atopic dermatitis were of relatively short duration and comprised a limited population with moderate-to-severe disease. Objective: The goal of the study was to evaluate the safety and efficacy over a 6-month period of tacrolimus 0.1% ointment in children and adults with a broader severity spectrum of atopic dermatitis. Methods: An open-label multicenter trial in patients 2 years and older was used. Primary safety and tolerability assessments included skin infection and application site adverse events. Efficacy parameters were body surface area involvement, pruritus score, and overall reponse. Results: There were 240 patients recruited at 23 study sites. Significant improvement from baseline was noted for all efficacy endpoints in both pediatric and adult patients. Skin infections occurred in 26% of patients. Burning sensation with product application, reported by 38% of patients, was transient and of mild-to-moderate severity in the majority. Conclusion: Tacrolimus 0.1% ointment was safe, well tolerated, and efficacious in treatment of atopic dermatitis in children and adults over six months.


2008 ◽  
Vol 33 (7) ◽  
pp. 545-549 ◽  
Author(s):  
Liat Attas-Fox ◽  
Yaniv Barkana ◽  
Vladimir Iskhakov ◽  
Svetlana Rayvich ◽  
Yariv Gerber ◽  
...  

2012 ◽  
Vol 24 (2) ◽  
pp. 144 ◽  
Author(s):  
Satoshi Takeuchi ◽  
Hidehisa Saeki ◽  
Shoji Tokunaga ◽  
Makoto Sugaya ◽  
Hanako Ohmatsu ◽  
...  

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