Re: Notes and comments on Efficacy, Safety, and Comparison of Sonic Hedgehog Inhibitors in Basal Cell Carcinomas: A Systematic Review and Meta-Analysis

2019 ◽  
Author(s):  
Philippe Lefrançois ◽  
Pingxing Xie ◽  
Khue H. Nguyen
Keyword(s):  
Systematic Review ◽  
Sonic Hedgehog ◽  
Basal Cell ◽  
Meta Analysis ◽  
Basal Cell Carcinomas

Recurrence rates following surgical excision of periocular basal cell carcinomas: systematic review and meta-analysis

2019 ◽  
Vol 31 (6) ◽  
pp. 597-601
Author(s):  
Kevin Phan ◽  
Lawrence J. Oh ◽  
Sourabh Goyal ◽  
Tim Rutherford ◽  
Anousha Yazdabadi
Keyword(s):  
Systematic Review ◽  
Basal Cell ◽  
Meta Analysis ◽  
Surgical Excision ◽  
Recurrence Rates ◽  
Basal Cell Carcinomas

Sonic Hedgehog Pathway Blockade After Surgical Debulk of Large Exophytic Basal Cell Carcinomas

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Paul J. Wirth ◽  
Ryan Hobbs ◽  
Elizabeth Billingsley ◽  
Allison T. Vidimos ◽  
Charlene Lam
Keyword(s):  
Sonic Hedgehog ◽  
Basal Cell ◽  
Hedgehog Pathway ◽  
Sonic Hedgehog Pathway ◽  
Basal Cell Carcinomas

scholarly journals The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets

2021 ◽  
Vol 4 (7) ◽  
pp. e202000651
Author(s):  
Ivan V Litvinov ◽  
Pingxing Xie ◽  
Scott Gunn ◽  
Denis Sasseville ◽  
Philippe Lefrançois
Keyword(s):  
Sonic Hedgehog ◽  
Basal Cell ◽  
Normal Skin ◽  
Sequencing Data ◽  
Human Malignancy ◽  
Basal Cell Carcinomas ◽  
Common Skin ◽  
Systemic Agents ◽  
Transcriptional Landscape ◽  
Common Malignancy

Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. Although most BCCs are easily managed, some are aggressive locally, require Mohs micrographic surgery, or can even metastasize. In the latter, resistance to Sonic Hedgehog inhibitors may occur. Despite their frequent occurrence in clinical practice, their transcriptional landscape remains poorly understood. By analyzing BCC RNA sequencing data according to clinically important features (all BCCs versus normal skin, high-risk versus low-risk BCCs based solely on histopathological subtypes with aggressive features, advanced versus non-advanced BCCs, and vismodegib-resistant versus vismodegib-sensitive tumors), we have identified novel differentially regulated genes and new targetable pathways implicated in BCC tumorigenesis. Pathways as diverse as IL-17, TLR, Akt/PI3K, cadherins, integrins, PDGF, and Wnt/β-catenin are promising therapeutic avenues for local and systemic agents in managing this common malignancy, including through drug re-purposing of existing medications. We experimentally validated several of these targets as biomarkers in our patient-derived cohort of primary BCC tumors.

The effectiveness of photodynamic therapy and cryotherapy on patients with basal cell carcinoma: A systematic review and meta‐analysis

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
George Mpourazanis ◽  
Pantelis Mpourazanis ◽  
Georgios Stogiannidis ◽  
Georgios Ntritsos
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Meta Analysis
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