scholarly journals TCT-300 Combining baseline distal-to-aortic pressure ratio and fractional flow reserve in the assessment of coronary stenosis severity

2015 ◽  
Vol 66 (15) ◽  
pp. B119
Author(s):  
Mauro Echavarria-Pinto ◽  
Tim P. van de Hoef ◽  
Martijn A. van Lavieren ◽  
Sukhjinder S. Nijjer ◽  
Borja Ibañez ◽  
...  
Keyword(s):  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Pressure Ratio ◽  
Aortic Pressure ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stenosis Severity

Combining Baseline Distal-to-Aortic Pressure Ratio and Fractional Flow Reserve in the Assessment of Coronary Stenosis Severity

2015 ◽  
Vol 8 (13) ◽  
pp. 1681-1691 ◽  
Author(s):  
Mauro Echavarría-Pinto ◽  
Tim P. van de Hoef ◽  
Martijn A. van Lavieren ◽  
Sukhjinder Nijjer ◽  
Borja Ibañez ◽  
...  
Keyword(s):  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Pressure Ratio ◽  
Aortic Pressure ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stenosis Severity

Fractional flow reserve

2021 ◽  
pp. 63-67
Author(s):  
Giovanni Ciccarelli ◽  
Emanuele Barbato ◽  
Bernard De Bruyne
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Coronary Intervention ◽  
Aortic Pressure ◽  
Fractional Flow ◽  
Coronary Pressure ◽  
Flow Reserve ◽  
Percutaneous Coronary

Fractional flow reserve is an index of the physiological significance of a coronary stenosis, defined as the ratio of maximal myocardial blood flow in the presence of the stenosis to the theoretically normal maximal myocardial blood flow (i.e. in the absence of the stenosis). This flow ratio can be calculated from the ratio of distal coronary pressure to central aortic pressure during maximal hyperaemia. More practically, fractional flow reserve indicates to what extent the epicardial segment can be responsible for myocardial ischaemia and, accordingly, fractional flow reserve quantifies the expected perfusion benefit from revascularization by percutaneous coronary intervention. Very limited evidence exists on the role on fractional flow reserve for bypass grafts.

Relationship between resting full‐cycle ratio and fractional flow reserve in assessments of coronary stenosis severity

2020 ◽  
Vol 96 (4) ◽  
Author(s):  
Takahiro Muroya ◽  
Hiroaki Kawano ◽  
Shiro Hata ◽  
Hiroki Shinboku ◽  
Koichiro Sonoda ◽  
...  
Keyword(s):  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stenosis Severity

Influence of hemodynamic conditions on fractional flow reserve: parametric analysis of underlying model

2002 ◽  
Vol 283 (4) ◽  
pp. H1462-H1470 ◽  
Author(s):  
Maria Siebes ◽  
Steven A. J. Chamuleau ◽  
Martijn Meuwissen ◽  
Jan J. Piek ◽  
Jos A. E. Spaan
Keyword(s):  
Fractional Flow Reserve ◽  
Aortic Pressure ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stenosis Severity ◽  
In Series ◽  
Resistive Model ◽  
Epicardial Stenosis ◽  
Microvascular Resistance ◽  
Diameter Reduction

Pressure-based fractional flow reserve (FFR) is used clinically to evaluate the functional severity of a coronary stenosis, by predicting relative maximal coronary flow (Qs/Qn). It is considered to be independent of hemodynamic conditions, which seems unlikely because stenosis resistance is flow dependent. Using a resistive model of an epicardial stenosis (0–80% diameter reduction) in series with the coronary microcirculation at maximal vasodilation, we evaluated FFR for changes in coronary microvascular resistance ( R cor= 0.2–0.6 mmHg · ml−1 · min), aortic pressure (Pa = 70–130 mmHg), and coronary outflow pressure (Pb = 0–15 mmHg). For a given stenosis, FFR increased with decreasing Pa or increasing R cor. The sensitivity of FFR to these hemodynamic changes was highest for stenoses of intermediate severity. For Pb > 0, FFR progressively exceeded Qs/Qn with increasing stenosis severity unless Pb was included in the calculation of FFR. Although the Pb-corrected FFR equaled Qs/Qn for a given stenosis, both parameters remained equally dependent on hemodynamic conditions, through their direct relationship to both stenosis and coronary resistance.

Influence of the position of the distal pressure measurement point on the Fractional Flow Reserve using in-silico simulations

2021 ◽  
Author(s):  
Rafael Agujetas ◽  
Conrado Ferrera ◽  
Reyes González-Fernández ◽  
Juan Nogales-Asensio ◽  
Ana Fernández-Tena
Keyword(s):  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Computational Simulation ◽  
Severe Heart Failure ◽  
Invasive Procedure ◽  
Clinical Decision ◽  
Aortic Pressure ◽  
Computed Tomographic Angiography ◽  
Fractional Flow ◽  
Flow Reserve

Abstract Coronary stenosis is largely responsible of severe heart failure as they can stop the blood flow to the myocardial. The Fractional Flow Reserve, the ratio of the mean distal coronary pressure to mean aortic pressure, is the most usual functional assessment of the severity of the coronary stenosis. In most cases, its value dictates the clinical decision to set a stent to restore the flow. Therefore, a correct measurement of this variable is crucial. The objective of this work is to evaluate how the Fractional Flow Reserve value is altered depending on the point where the distal pressure is measured. This information can be very important to prevent cardiologists from making the wrong clinical decisions. From the data taken from anonymous patients who underwent Coronary Computed Tomographic Angiography and cardiac catheterization, a comparison was made with the results of a computational simulation of the model reconstructed from the angiography. The results of the Fractional Flow Reserve obtained by simulation (0.834) agree with those obtained experimentally (0.830), difference less than 0.8%, which indicates that with simulation more results can be obtained than experimentally would be impossible to achieve. The actual invasive procedure to measure the Fractional Flow Reserve is being executed with a protocol that do not consider the influence of the location on the distal pressure value. The new procedure would avoid false results related to the point where the distal pressure is measured.

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