Diagnosis of red meat allergy with antigen-specific IgE tests in serum

2017 ◽  
Vol 140 (2) ◽  
pp. 608-610.e5 ◽  
Author(s):  
Jonathan R. Brestoff ◽  
Mark A. Zaydman ◽  
Mitchell G. Scott ◽  
Ann M. Gronowski
Keyword(s):  
Specific Ige ◽  
Red Meat ◽  
Meat Allergy ◽  
Red Meat Allergy

scholarly journals The first reported cases of meat allergy following tick bites in the UK

JRSM Open ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 205427042199613
Author(s):  
Rhea A Bansal ◽  
Sameer Bahal ◽  
Rachael O’Brien ◽  
Joanne Miller ◽  
Amolak S Bansal ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Specific Ige ◽  
Red Meat ◽  
Type I ◽  
Tick Bites ◽  
Meat Allergy ◽  
Red Meat Allergy ◽  
Delayed Reactions ◽  
The Uk ◽  
Red Meats

Allergic reactions frequently involve the production of immunoglobulin E (IgE) antibodies to proteins. However, reactions directed against carbohydrate moieties are increasingly being recognised. Tick bites can contribute to the development of immunoglobulin E to the galactose-1,3-galactose (alpha-gal) moiety on tick salivary proteins. These IgE molecules can cross-react with alpha-gal found in red meats, causing Type I IgE-mediated hypersensitivity reactions to these foods. We present three cases of delayed reactions to beef, pork and lamb in patients with prior tick bites and in the presence of a positive-specific IgE to alpha-gal. Patients were advised to avoid red meat consumption and to carry emergency treatment in the form of anti-histamines with or without adrenaline autoinjector devices. This is the first published report of red meat allergy caused by tick bites suffered in the UK.

scholarly journals Determining the link between alpha-gal-containing antigens in North American ticks and red meat allergy

2018 ◽  
Author(s):  
Gary Crispell ◽  
Scott P. Commins ◽  
Stephanie A. Archer-Hartman ◽  
Shailesh Choudhary ◽  
Guha Dharmarajan ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Tick Species ◽  
Gulf Coast ◽  
Specific Ige ◽  
Dermacentor Variabilis ◽  
Red Meat ◽  
Amblyomma Americanum ◽  
Future Research ◽  
Meat Allergy ◽  
Red Meat Allergy

AbstractDevelopment of specific IgE antibodies to the oligosaccharide galactose-α-1, 3-galactose (α-gal) following tick bites has been shown to be the source of red meat allergy. In this study, we investigated the presence of α-gal in four tick species: the lone-star tick (Amblyomma americanum), the Gulf-Coast tick (Amblyomma maculatum), the American dog tick (Dermacentor variabilis), and the black-legged tick (Ixodes scapularis) by using a combination of immunoproteome, carbohydrate analysis, and basophil activation approaches. Using anti-α-gal antibodies, α-gal was identified in the salivary glands of bothAm. americanumandIx. scapularis, whileAm. maculatumandDe. variabilisappeared to lack the sugar. PNGase F treatment confirmed the deglycosylation of N-linked α-gal-containing proteins in tick salivary glands. Immunolocalization of α-gal moieties to the salivary secretory vesicles of the salivary acini also confirmed the secretory nature of α-gal-containing antigens in ticks.Am. americanumticks were fed human blood (lacks α-gal) using an artificial membrane feeding system to determine the source of α-gal. N-linked glycan analysis revealed thatAm. americanumandIx. scapularishave α-gal in their saliva and salivary glands, butAm. maculatumcontains no detectable quantity. Salivary samples fromAm. americanumandIx. scapularisstimulated activation of basophils primed with plasma from α-gal allergic subjects. Together, our data support the idea that bites from certain tick species may specifically create a risk for the development of α-gal-specific IgE and hypersensitivity reactions in humans. Alpha-Gal syndrome challenges the current food allergy paradigm and broadens opportunities for future research.

Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tickIxodes ricinus; possible relationship with red meat allergy

Allergy ◽  
2013 ◽  
Vol 68 (4) ◽  
pp. 549-552 ◽  
Author(s):  
C. Hamsten ◽  
M. Starkhammar ◽  
T. A. T. Tran ◽  
M. Johansson ◽  
U. Bengtsson ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Red Meat ◽  
Meat Allergy ◽  
Red Meat Allergy

The red meat allergy syndrome in Sweden

2016 ◽  
Vol 25 (2) ◽  
pp. 29-34 ◽  
Author(s):  
Danijela Apostolovic ◽  
Thi Anh Thu Tran ◽  
Maria Starkhammar ◽  
Sara Sánchez-Vidaurre ◽  
Carl Hamsten ◽  
...  
Keyword(s):  
Red Meat ◽  
Meat Allergy ◽  
Red Meat Allergy

scholarly journals Red meat allergy in Sweden: Association with tick sensitization and B-negative blood groups

2013 ◽  
Vol 132 (6) ◽  
pp. 1431-1434.e6 ◽  
Author(s):  
Carl Hamsten ◽  
Thi Anh T. Tran ◽  
Maria Starkhammar ◽  
Annelie Brauner ◽  
Scott P. Commins ◽  
...  
Keyword(s):  
Red Meat ◽  
Blood Groups ◽  
Meat Allergy ◽  
Red Meat Allergy

scholarly journals The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy

Allergy ◽  
2016 ◽  
Vol 72 (2) ◽  
pp. 266-273 ◽  
Author(s):  
D. Kollmann ◽  
B. Nagl ◽  
C. Ebner ◽  
W. Emminger ◽  
S. Wöhrl ◽  
...  
Keyword(s):  
Red Meat ◽  
Specific Antibodies ◽  
Meat Allergy ◽  
Red Meat Allergy

scholarly journals Red meat allergy: clinical characteristics

2020 ◽  
Vol 8 (3) ◽  
pp. 142
Author(s):  
Sejin Kim ◽  
Jaechun Lee ◽  
Ara Ko
Keyword(s):  
Clinical Characteristics ◽  
Red Meat ◽  
Meat Allergy ◽  
Red Meat Allergy

scholarly journals A Case of α-Gal-Unrelated Red Meat-Induced Urticaria Treated by Omalizumab

2021 ◽  
pp. 437-440
Author(s):  
Makoto Kondo ◽  
Yoshiaki Matsushima ◽  
Shohei Iida ◽  
Ai Umaoka ◽  
Takehisa Nakanishi ◽  
...  
Keyword(s):  
Chronic Urticaria ◽  
Challenge Test ◽  
Healthy Woman ◽  
Food Challenge ◽  
Red Meat ◽  
Meat Allergy ◽  
Red Meat Allergy ◽  
History Of ◽  
Food Challenge Test ◽  
Repeatability Test

A 70-year-old healthy woman was referred to our hospital for chronic urticaria. She did not have a history of allergy, asthma, and rhinitis. She was initially diagnosed with α-gal-related urticaria based on an episode of delayed-type urticaria after eating red meat. The results of the intracutaneous allergen test for beef and pork were negative. Fluorenzyme immunoassays specific for IgE against α-gal, beef, and pork were also negative. She was diagnosed with an α-gal-unrelated red meat allergy following the reproduction of urticaria by a food challenge test. The patient was unresponsive to several drugs, including antihistamines or immunosuppressants. However, omalizumab administration suppressed her symptoms. <b><i>Key Clinical Message:</i></b> The diagnosis of red meat allergy may require a repeatability test by consuming red meat even though serum α-gal IgE antibody might be negative. The α-gal-unrelated red meat urticaria may be responsive to omalizumab.

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