[P2-358]: IN VIVO MAPPING OF TAU DEPOSITION, PERFUSION, AND CORTICAL THINNING IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE

Aging-associated cognitive impairment is an important health care issue since individuals with mild cognitive impairment are more likely to develop Alzheimer’s disease. In the present study, the protective effect of Gossypium herbaceam extracts (GHE) on learning and memory impairment associated with aging were examined in vivo using Morris water maze and step through task. Furthermore, the antioxidant activity and neuroprotective effect of GHE was investigated with methods of histochemistry and biochemistry. These data showed that oral administration with GHE at the doses of 35, 70, and 140 mg/kg exerted an improved effect on the learning and memory impairment in aged rats. Subsequently, GHE afforded a beneficial action on eradication of free radicals without influence on the activity of glutathione peroxidase and superoxide dismutase. GHE treatment enhanced the expression levels of nerve growth factor. Meanwhile, proliferation of neural progenitor cells was elevated in hippocampus after treatment with GHE. Taken together, neurogenic niche improvement could be involved in the mechanism underlying neuroprotection of GHE against aging-associated cognitive impairment. These findings suggested that GHE might be a potential agent as cognitive-enhancing drugs that delay or halt mild cognitive impairment progression to Alzheimer’s disease or treatment of aging-associated cognitive impairment.

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Relevance of in vivo Neurophysiological Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-2012-112093 ◽

2012 ◽

Vol 31 (s3) ◽

pp. S137-S154 ◽

Cited By ~ 10

Author(s):

Takao Yamasaki ◽

Shizuka Horie ◽

Hiroyuki Muranaka ◽

Yumiko Kaseda ◽

Yasuyo Mimori ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment

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The Use of the Gaps-In-Noise Test as an Index of the Enhanced Left Temporal Cortical Thinning Associated with the Transition between Mild Cognitive Impairment and Alzheimer’s Disease

Journal of the American Academy of Audiology ◽

10.3766/jaaa.16075 ◽

2017 ◽

Vol 28 (05) ◽

pp. 463-471 ◽

Cited By ~ 14

Author(s):

Vasiliki Vivian Iliadou ◽

Doris-Eva Bamiou ◽

Christos Sidiras ◽

Nikolaos P. Moschopoulos ◽

Magda Tsolaki ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Temporal Resolution ◽

Auditory Processing ◽

Auditory Perception ◽

Central Auditory Processing ◽

Hearing Sensitivity ◽

Cortical Thinning

Background: The known link between auditory perception and cognition is often overlooked when testing for cognition. Purpose: To evaluate auditory perception in a group of older adults diagnosed with mild cognitive impairment (MCI). Research Design: A cross-sectional study of auditory perception. Study Sample: Adults with MCI and adults with no documented cognitive issues and matched hearing sensitivity and age. Data collection: Auditory perception was evaluated in both groups, assessing for hearing sensitivity, speech in babble (SinB), and temporal resolution. Results: Mann–Whitney test revealed significantly poorer scores for SinB and temporal resolution abilities of MCIs versus normal controls for both ears. The right-ear gap detection thresholds on the Gaps-In-Noise (GIN) Test clearly differentiated between the two groups (p < 0.001), with no overlap of values. The left ear results also differentiated the two groups (p < 0.01); however, there was a small degree of overlap #x02DC;8-msec threshold values. With the exception of the left-ear inattentiveness index, which showed a similar distribution between groups, both impulsivity and inattentiveness indexes were higher for the MCIs compared to the control group. Conclusions: The results support central auditory processing evaluation in the elderly population as a promising tool to achieve earlier diagnosis of dementia, while identifying central auditory processing deficits that can contribute to communication deficits in the MCI patient population. A measure of temporal resolution (GIN) may offer an early, albeit indirect, measure reflecting left temporal cortical thinning associated with the transition between MCI and Alzheimer’s disease.

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P1-335: In vivo localization of aging and Alzheimer's disease effects on cortical gray matter in normal elderly and patients with mild cognitive impairment

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.615 ◽

2011 ◽

Vol 7 ◽

pp. S219-S219

Author(s):

Annapaola Prestia ◽

Annalisa Baglieri ◽

Matteo Bonetti ◽

Paul Rasser ◽

Paul Thompson ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Gray Matter ◽

Cortical Gray Matter

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Long-Term Exposure to PM10 and in vivo Alzheimer’s Disease Pathologies

Advances in Alzheimer’s Disease - Alzheimer’s Disease and Air Pollution ◽

10.3233/aiad210012 ◽

2021 ◽

Author(s):

Jun Ho Lee ◽

Min Soo Byun ◽

Dahyun Yi ◽

Kang Ko ◽

So Yeon Jeon ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Amyloid Β ◽

Aerodynamic Diameter ◽

Cognitively Normal ◽

Study Population

Background: Previous studies indicated an association between Alzheimer’s disease (AD) dementia and air particulate matter (PM) with aerodynamic diameter <10 μm (PM10), as well as smaller PM. Limited information, however, is available for the neuropathological links underlying such association. Objective: This study aimed to investigate the relationship between long-term PM10 exposure and in vivo pathologies of AD using multimodal neuroimaging. Methods: The study population consisted of 309 older adults without dementia (191 cognitively normal and 118 mild cognitive impairment individuals), who lived in Republic of Korea. Participants underwent comprehensive clinical assessments, 11C-Pittsburg compound B (PiB) positron emission tomography (PET), and magnetic resonance imaging scans. A subset of 78 participants also underwent 18F-AV-1451 tau PET evaluation. The mean concentration of PM with aerodynamic diameter <10 μm over the past 5 years (PM10mean) collected from air pollution surveillance stations were matched to each participant’s residence. Results: In this non-demented study population, of which 62% were cognitively normal and 38% were in mild cognitive impairment state, exposure to the highest tertile of PM10mean was associated with increased risk of amyloid-β (Aβ) positivity (odds ratio 2.19, 95% confidence interval 1.13 to 4.26) even after controlling all potential confounders. In contrast, there was no significant associations between PM10mean exposure and tau accumulation. AD signature cortical thickness and white matter hyperintensity volume were also not associated with PM10mean exposure. Conclusion: The findings suggest that long-term exposure to PM10 may contribute to pathological Aβ deposition.

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