Presenting Neutrophil-to-Lymphocyte Ratio is Associated with Resectability After Neoadjuvant Therapy in Borderline Resectable Pancreatic Cancer

2015 ◽  
Vol 221 (4) ◽  
pp. S144-S145
Author(s):  
June S. Peng ◽  
Trang K. Nguyen ◽  
Sricharan Chalikonda ◽  
Jane S. Wey ◽  
R. Matthew Walsh ◽  
...  
2019 ◽  
Author(s):  
Francis Igor Macedo ◽  
Danny Yakoub ◽  
Vikas Dudeja ◽  
Nipun B. Merchant

The incidence of pancreatic cancer continues to rise, and it is now the third-leading cause of cancer-related deaths in the United States. Only 15 to 20% of patients are eligible to undergo potentially curative resection, as most tumors are deemed unresectable at the time of diagnosis because of either locally advanced disease or distant metastases. Improvements in preoperative CT imaging have enabled better determination of the extent of disease and allowed for better operative planning. Based on their relationship to the surrounding vasculature and structures and presence or absence of distant disease, pancreatic tumors are classified into four categories: resectable, borderline resectable pancreatic cancer (BRPC), locally advanced pancreatic cancer (LAPC), and metastatic. With the recent advent of more effective chemotherapy regimens, efforts have focused on using neoadjuvant therapy approaches to increase the likelihood of achieving an R0 in patients with BRPC and possibly convert unresectable, locally advanced tumors to potentially resectable tumors. Response with neoadjuvant therapy regimens has resulted in increased number of patients eligible for resection, many times requiring vascular resection. Herein, we describe recent changes in the classification, important surgical and pathologic considerations and updated multimodal therapeutic options in the complex management of BRPC and LAPC.  This review contains 5 figures, 2 tables, and 78 references. Key Words: borderline resectable pancreatic cancer, CA 19-9, FOLFIRINOX, locally advanced pancreatic cancer, nab-paclitaxel, neoadjuvant chemotherapy, pancreatectomy, portal vein resection, radiation therapy, gemcitabine


2019 ◽  
Vol 18 (4) ◽  
pp. 373-378 ◽  
Author(s):  
June S Peng ◽  
Jane Wey ◽  
Sricharan Chalikonda ◽  
Daniela S Allende ◽  
R Matthew Walsh ◽  
...  

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