High-performance liquid chromatographic determination of acetyl-11-keto-α-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: Application in pharmacokinetic studies

2005 ◽  
Vol 829 (1-2) ◽  
pp. 144-148 ◽  
Author(s):  
Berthold Büchele ◽  
Waltraud Zugmaier ◽  
Felicitas Genze ◽  
Thomas Simmet
Keyword(s):  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Pharmacokinetic Studies ◽  
Photodiode Array Detection ◽  
Pentacyclic Triterpenoid ◽  
Photodiode Array ◽  
Array Detection ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

scholarly journals Liquid Chromatographic Determination of Five Benzoylurea Insecticides in Fruit and Vegetables

1998 ◽  
Vol 81 (5) ◽  
pp. 1037-1042 ◽  
Author(s):  
Miguel Gamón ◽  
Adolfo Saez ◽  
Rosa Pelegrí ◽  
Inmaculada Peris ◽  
Josá G De La Cuadra ◽  
...  
Keyword(s):  
Solid Phase ◽  
Chromatographic Determination ◽  
Photodiode Array Detection ◽  
Photodiode Array ◽  
Array Detection ◽  
Liquid Chromatographic Determination ◽  
Benzoylurea Insecticides ◽  
Vegetables And Fruits ◽  
Liquid Chromatographic

Abstract A liquid chromatographic (LC) method was developed to determine 5 benzoyl ureas—diflubenzuron, hexaflumuron, teflubenzuron, flufenozuron, and lufenuron—in peppers, tomatoes, eggplants, cucumbers, and oranges. Preparation of samples involve extraction with acetone and partitioning into dichloromethane-petroleum ether. A portion of this extract is cleaned up with a solid-phase extraction aminopropyl disposable column. With LC analysis using an RP-8-DB microbore column, acetonitrilewater (70 + 30, v/v) as mobile phase, and photodiode array detection at 254 nm, recovery and repeatability data were collected for the 5 benzoylureas on 4 vegetables and citrus in the range 0.04-2.0 mg/kg. Validated limits of detection and quantitation were 0.01 and 0.04 mg/kg, respectively. The method is reliable for routine analysis of vegetables and fruits

Liquid-chromatographic determination of 5-fluorocytosine.

1980 ◽  
Vol 26 (1) ◽  
pp. 117-119
Author(s):  
J O Miners ◽  
T Foenander ◽  
D J Birkett
Keyword(s):  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Therapeutic Monitoring ◽  
Pharmacokinetic Studies ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract We report a "high-performance" liquid-chromatographic method for measuring 5-fluorocytosine in plasma and cerebrospinal fluid. After deproteinization with trichloroacetic acid, the supernates are chromatographed on a reversed-phase (C18) column. Response to concentration is linear in the range of 5 to 200 mg/L, with ultraviolet detection at 276 nm. The assay requires only 0.1 mL of plasma, is reproducible, and may be performed in less than 12 min. 5-Fluorocytosine concentrations determined by this procedure correlated well with those obtained by spectrofluorometry, although the present method is more specific with no observable interference from co-administered amphotericin B and most other commonly encountered drugs, including salicylat:. This method is applicable to the routine therapeutic monitoring of pediatric and adult patients as well as to pharmacokinetic studies.

Liquid-chromatographic determination of 5-fluorocytosine.

1980 ◽  
Vol 26 (1) ◽  
pp. 117-119 ◽  
Author(s):  
J O Miners ◽  
T Foenander ◽  
D J Birkett
Keyword(s):  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Therapeutic Monitoring ◽  
Pharmacokinetic Studies ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract We report a "high-performance" liquid-chromatographic method for measuring 5-fluorocytosine in plasma and cerebrospinal fluid. After deproteinization with trichloroacetic acid, the supernates are chromatographed on a reversed-phase (C18) column. Response to concentration is linear in the range of 5 to 200 mg/L, with ultraviolet detection at 276 nm. The assay requires only 0.1 mL of plasma, is reproducible, and may be performed in less than 12 min. 5-Fluorocytosine concentrations determined by this procedure correlated well with those obtained by spectrofluorometry, although the present method is more specific with no observable interference from co-administered amphotericin B and most other commonly encountered drugs, including salicylat:. This method is applicable to the routine therapeutic monitoring of pediatric and adult patients as well as to pharmacokinetic studies.

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