Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery

2012 ◽  
Vol 40 (8) ◽  
pp. e346-e349 ◽  
Author(s):  
Fábio Andrey da Costa Araújo ◽  
Thiago de Santana Santos ◽  
Hécio Henrique Araújo de Morais ◽  
José Rodrigues Laureano Filho ◽  
Emanuel Dias de Oliveira e Silva ◽  
...  
2013 ◽  
Vol 27 (3) ◽  
pp. 266-271 ◽  
Author(s):  
José Leonardo Simone ◽  
Waldyr Antonio Jorge ◽  
Anna Carolina Ratto Tempestini Horliana ◽  
Talita Girio Canaval ◽  
Isabel Peixoto Tortamano

Author(s):  
COREY DECOTEAU ◽  
CHRISTOPHER R. PAOLINO ◽  
HARSHIV VYAS ◽  
MATTHEW FINKELMAN ◽  
MARIA B. PAPAGEORGE ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Long Xie ◽  
Lei Sang ◽  
Zhi Li

Abstract Background How to prevent pain after the extraction of impacted teeth is a serious challenge for all patients. The purpose of this clinical trial was to investigate whether pre-emptive low dose of etoricoxib can reduce postoperative pain in patients undergoing third molars surgery. Methods Patients were randomised to receive etoricoxib 60 mg or placebo 30 min before surgery. Post-operative pain was recorded using a visual analogue scale during 24 h within the post-operative period. The total dose of ibuprofen rescue intake was recorded. Kaplan–Meier curves and log-rank analyses were used to evaluate the proportion of patients without rescue analgesic. Results Scores for the post-operative pain in the etoricoxib group were significantly lower than those in the placebo group during first 12 h (p < 0.05). The number of patients without analgesic rescue medication was significantly lower in the etoricoxib group than in the placebo group. The average amount of rescue medication in the etoricoxib group (0.4 ± 0.9 dose) was lower than that in the placebo group (1.1 ± 0.9 doses, p = 0.004). Etoricoxib resulted in the long-term survival of patients without rescue analgesic (p < 0.001). Conclusions This study revealed that etoricoxib has a substantial pre-emptive analgesic effect, resulting in the reduced use of analgesics after third molar removal. Trial registration: Registered on ChiCTR1900024503. Date of Registration: 13/07/2019.


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