scholarly journals High volume plasma exchange in patients with acute liver failure

2016 ◽  
Vol 65 (3) ◽  
pp. 646-647 ◽  
Author(s):  
Jacques Bernuau
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
High Volume

scholarly journals Therapeutic plasma exchange in children with acute liver failure (ALF): is it time for incorporation into the ALF armamentarium?

2021 ◽  
Author(s):  
Emma C. Alexander ◽  
Akash Deep
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Controlled Trial ◽  
High Volume ◽  
Systemic Circulation ◽  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Randomised Controlled ◽  
Liver Assist Devices

AbstractPaediatric acute liver failure (PALF) is a rare but devastating condition with high mortality. An exaggerated inflammatory response is now recognised as pivotal in the pathogenesis and prognosis of ALF, with cytokine spill from the liver to systemic circulation implicated in development of multi-organ failure associated with ALF. With advances in medical management, especially critical care, there is an increasing trend towards spontaneous liver regeneration, averting the need for emergency liver transplantation or providing stability to the patient awaiting a graft. Hence, research is ongoing for therapies, including extracorporeal liver support devices, that can bridge patients to transplant or spontaneous liver recovery. Considering the immune-related pathogenesis and inflammatory phenotype of ALF, plasma exchange serves as an ideal liver assist device as it performs both the excretory and synthetic functions of the liver and, in addition, works as an immunomodulatory therapy by suppressing the early innate immune response in ALF. After a recent randomised controlled trial in adults demonstrated a beneficial effect of high-volume plasma exchange on clinical outcomes, this therapy was incorporated in European Association for the Study of Liver (EASL) recommendations for managing adult patients with ALF, but no guidelines exist for PALF. In this review, we discuss rationale, timing, practicalities, and existing evidence regarding the use of plasma exchange as an immunomodulatory treatment in PALF. We discuss controversies in delivery of this therapy as an extracorporeal device, and practicalities of use of plasma exchange as a ‘hybrid’ therapy alongside other extracorporeal liver assist devices, before finally reviewing outstanding research questions for the future.

High volume plasma exchange in acute liver failure: Dampening the inflammatory cascade?

2016 ◽  
Vol 64 (1) ◽  
pp. 10-12 ◽  
Author(s):  
Constantine J. Karvellas ◽  
R. Todd Stravitz
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
High Volume ◽  
Inflammatory Cascade

High-volume plasma exchange in a patient with acute liver failure due to non-exertional heat stroke in a sauna

2014 ◽  
Vol 29 (5) ◽  
pp. 281-283 ◽  
Author(s):  
Kuan-Jung Chen ◽  
Tso-Hsiao Chen ◽  
Yuh-Mou Sue ◽  
Tzay-Jinn Chen ◽  
Chung-Yi Cheng
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Heat Stroke ◽  
High Volume ◽  
Exertional Heat Stroke

scholarly journals High Volume Plasma Exchange in Acute Liver Failure

2021 ◽  
Author(s):  
A. Tharwani ◽  
A. Bhardwaj ◽  
M. Aggarwal ◽  
H. Einchenlaub ◽  
K. Kommaraju ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
High Volume

Successful treatment of drug-induced acute liver failure with high-volume plasma exchange

2013 ◽  
Vol 28 (6) ◽  
pp. 430-434 ◽  
Author(s):  
Chung-Te Liu ◽  
Tso-Hsiao Chen ◽  
Chung-Yi Cheng
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Successful Treatment ◽  
High Volume ◽  
Drug Induced

scholarly journals High-volume plasma exchange in patients with acute liver failure: an open randomized controlled trial

2015 ◽  
Vol 88 (6) ◽  
pp. 1215-1216 ◽  
Author(s):  
Andrew Davenport ◽  
Tilman B. Drüeke ◽  
Masaomi Nangaku ◽  
P. Toby Coates
Keyword(s):  
Randomized Controlled Trial ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Controlled Trial ◽  
High Volume ◽  
Randomized Controlled

High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial

2016 ◽  
Vol 64 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Fin Stolze Larsen ◽  
Lars Ebbe Schmidt ◽  
Christine Bernsmeier ◽  
Allan Rasmussen ◽  
Helena Isoniemi ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Controlled Trial ◽  
High Volume ◽  
Randomised Controlled

Initial experience with high‐volume plasma exchange in patients with acute liver failure

2021 ◽  
Author(s):  
Ji Eun Kim ◽  
Sejong Chun ◽  
Dong Hyun Sinn ◽  
Nam Joong Kim ◽  
Semi Kim ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
High Volume ◽  
Initial Experience

Reversal of Acute Liver Failure Due to Wilson Disease by a Regimen of High‐Volume Plasma Exchange and Penicillamine

Hepatology ◽  
2019 ◽  
Vol 69 (4) ◽  
pp. 1835-1837 ◽  
Author(s):  
Jakob Damsgaard ◽  
Fin Stolze Larsen ◽  
Henriette Ytting
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Wilson Disease ◽  
High Volume
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