Regional point prevalence study of healthcare-associated infections and antimicrobial use in acute care hospitals in Liguria, Italy

Background A point prevalence survey (PPS) on healthcare-associated infections (HAI) and antimicrobial use was conducted in Swiss acute care hospitals in 2017. Aim Our objective was to assess antimicrobial use in Swiss acute care hospitals. Methods All patients hospitalised in any acute care hospital in Switzerland were eligible. We used the most recent version of the PPS protocol of the European Centre for Disease Prevention and Control. Results Data from 12,931 patients of 96 hospitals were collected. Of these, 4,265 (33%; 95% confidence interval (CI): 32.2–33.8) were on 5,354 antimicrobials for 4,487 indications. Most of the 2,808 therapeutic indications addressed 1,886 community-acquired infections (67.2%; 95% CI: 65.4–68.9). Of the 1,176 surgical prophylaxes, 350 (29.8%; 95% CI: 27.1–32.4) exceeded the duration of 1 day. Of the 1,090 antimicrobial regimens that were changed, 309 (28.3%; 95% CI: 25.7–31.0) were escalated and 337 (30.9%; 95% CI: 28.2–33.7) were de-escalated. Amoxicillin/clavulanic acid was the most frequent antimicrobial (18.8%; 95% CI: 17.7–19.8), prescribed mainly for therapeutic indications (76.0%; 95% CI: 73.3–78.7). A total of 1,931 (37.4%; 95% CI: 36.1–38.8) of the 5,158 antimicrobials for systemic use were broad-spectrum antibiotics, most frequently third- and fourth-generation cephalosporins (35.9%; 95% CI: 33.8–38.1). Conclusions Antimicrobial consumption was at European average, the use of broad-spectrum antibiotics in the lower third. Swiss acute care hospitals should invest in antimicrobial stewardship, particularly in reducing the use of broad-spectrum antibiotics.

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Development of case vignettes for assessment of the inter-rater variability of national validation teams for the point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals

Journal of Hospital Infection ◽

10.1016/j.jhin.2019.01.018 ◽

2019 ◽

Vol 101 (4) ◽

pp. 455-460 ◽

Cited By ~ 1

Author(s):

E. van Hauwermeiren ◽

E. Iosifidis ◽

T. Kärki ◽

C. Suetens ◽

P. Kinross ◽

...

Keyword(s):

Acute Care ◽

Acute Care Hospitals ◽

Point Prevalence ◽

Antimicrobial Use ◽

Healthcare Associated Infections ◽

Prevalence Survey ◽

Point Prevalence Survey ◽

Case Vignettes ◽

Rater Variability ◽

Healthcare Associated

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Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017

Eurosurveillance ◽

10.2807/1560-7917.es.23.46.1800393 ◽

2018 ◽

Vol 23 (46) ◽

Cited By ~ 28

Author(s):

Diamantis Plachouras ◽

Tommi Kärki ◽

Sonja Hansen ◽

Susan Hopkins ◽

Outi Lyytikäinen ◽

...

Keyword(s):

Acute Care ◽

Antimicrobial Agents ◽

Acute Care Hospitals ◽

Point Prevalence ◽

Antimicrobial Use ◽

Healthcare Associated Infections ◽

Surgical Prophylaxis ◽

Prevalence Survey ◽

Point Prevalence Survey ◽

Healthcare Associated

Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms. In 2016–17, we performed the second point-prevalence survey (PPS) of healthcare-associated infections (HAIs) and antimicrobial use in European acute care hospitals. We included 1,209 hospitals and 310,755 patients in 28 of 31 European Union/European Economic Area (EU/EEA) countries. The weighted prevalence of antimicrobial use in the EU/EEA was 30.5% (95% CI: 29.2–31.9%). The most common indication for prescribing antimicrobials was treatment of a community-acquired infection, followed by treatment of HAI and surgical prophylaxis. Over half (54.2%) of antimicrobials for surgical prophylaxis were prescribed for more than 1 day. The most common infections treated by antimicrobials were respiratory tract infections and the most commonly prescribed antimicrobial agents were penicillins with beta-lactamase inhibitors. There was wide variation of patients on antimicrobials, in the selection of antimicrobial agents and in antimicrobial stewardship resources and activities across the participating countries. The results of the PPS provide detailed information on antimicrobial use in European acute care hospitals, enable comparisons between countries and hospitals, and highlight key areas for national and European action that will support efforts towards prudent use of antimicrobials.

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A national point prevalence study on healthcare-associated infections and antimicrobial use in Austria

Wiener klinische Wochenschrift ◽

10.1007/s00508-015-0947-8 ◽

2016 ◽

Vol 128 (3-4) ◽

pp. 89-94 ◽

Cited By ~ 12

Author(s):

Luigi Segagni Lusignani ◽

Alexander Blacky ◽

Peter Starzengruber ◽

Magda Diab-Elschahawi ◽

Thomas Wrba ◽

...

Keyword(s):

Point Prevalence ◽

Prevalence Study ◽

Antimicrobial Use ◽

Healthcare Associated Infections ◽

Point Prevalence Study ◽

Healthcare Associated

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Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey

Clinical Infectious Diseases ◽

10.1093/cid/cix103 ◽

2017 ◽

Vol 64 (suppl_2) ◽

pp. S61-S67 ◽

Cited By ~ 35

Author(s):

Yiying Cai ◽

Indumathi Venkatachalam ◽

Nancy W. Tee ◽

Thean Yen Tan ◽

Asok Kurup ◽

...

Keyword(s):

Acute Care ◽

Acute Care Hospitals ◽

Point Prevalence ◽

Antimicrobial Use ◽

Healthcare Associated Infections ◽

Prevalence Survey ◽

Point Prevalence Survey ◽

Healthcare Associated

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A nationwide assessment of the burden of healthcare-associated infections and antimicrobial use among surgical patients: results from Serbian point prevalence survey, 2017

Antimicrobial Resistance and Infection Control ◽

10.1186/s13756-021-00889-9 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Vesna Šuljagić ◽

Milica Bajčetić ◽

Vesna Mioljević ◽

Gorana Dragovac ◽

Biljana Mijović ◽

...

Keyword(s):

Acute Care ◽

Acute Care Hospitals ◽

Point Prevalence ◽

Surgical Patients ◽

Antimicrobial Use ◽

Healthcare Associated Infections ◽

Extrinsic Factors ◽

Prevalence Survey ◽

Point Prevalence Survey ◽

Healthcare Associated

Abstract Background As the only non-European Union (EU) country, Serbia participated in a second point prevalence survey of healthcare-associated infections (HAIs) and antimicrobial use (AMU) organized by the European Centre for Disease Prevention and Control (ECDC) in the EU countries. Here, we aimed to estimate the prevalence of HAI and AMU in patients who had recently undergone a surgery and to compare risk profile, HAI rates, and AMU among surgical patients and non-surgical patients. Methods A national PPS was performed in 65 Serbian acute-care hospitals, in November 2017. In this paper, the data of 61 hospitals for adult acute-care were analyzed. To ensure the comparability of study design we used the Serbian translation of ECDC case definitions and ECDC PPS protocol. The trained infection control staff, led by a hospital coordinator, reviewed medical records to identify HAI active at the time of the survey and AMU. Only inpatients admitted to the ward before 8 a.m. on the day if the survey were included. Results A total of 12,478 patients from 61 hospitals for adult acute-care were eligible for inclusion in this study. Significantly higher proportions of surgical patients were female, belonged to the 60-to-79 age group, and were less severely ill. Also, extrinsic factors (invasive devices, hospitalization at the ICU, and prior antibiotics therapy) were more frequent in surgical patients. Prevalence of HAIs was higher among surgical patients (261/3626; 7.2%) than among non-surgical patients (258/8852; 2.9%) (p < 0.0001). The highest prevalence of all HAIs was noted in patients who had kidney transplantation (4/11; 36.4%), while SSIs were the most prevalent among patients who had peripheral vascular bypass surgery (3/15; 20.0%). Non-surgical patients received treatment for community-acquired infections in significantly higher proportion (2664/8852; 64.3) (p < 0.001). Surgical prophylaxis for more than 1 day was applied in 71.4% of surgical patients. Conclusion We have provided an insight into the burden of HAIs and AMU among Serbia acute-care hospitals, and highlighted several priority areas and targets for quality improvement.

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Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: results from two European point prevalence surveys, 2016 to 2017

Eurosurveillance ◽

10.2807/1560-7917.es.2018.23.46.1800516 ◽

2018 ◽

Vol 23 (46) ◽

Cited By ~ 79

Author(s):

Carl Suetens ◽

Katrien Latour ◽

Tommi Kärki ◽

Enrico Ricchizzi ◽

Pete Kinross ◽

...

Keyword(s):

Antimicrobial Resistance ◽

Acute Care ◽

Long Term Care ◽

Acute Care Hospitals ◽

Point Prevalence ◽

Healthcare Associated Infections ◽

Term Care ◽

Care Facilities ◽

Healthcare Associated

Point prevalence surveys of healthcare-associated infections (HAI) and antimicrobial use in the European Union and European Economic Area (EU/EEA) from 2016 to 2017 included 310,755 patients from 1,209 acute care hospitals (ACH) in 28 countries and 117,138 residents from 2,221 long-term care facilities (LTCF) in 23 countries. After national validation, we estimated that 6.5% (cumulative 95% confidence interval (cCI): 5.4–7.8%) patients in ACH and 3.9% (95% cCI: 2.4–6.0%) residents in LTCF had at least one HAI (country-weighted prevalence). On any given day, 98,166 patients (95% cCI: 81,022–117,484) in ACH and 129,940 (95% cCI: 79,570–197,625) residents in LTCF had an HAI. HAI episodes per year were estimated at 8.9 million (95% cCI: 4.6–15.6 million), including 4.5 million (95% cCI: 2.6–7.6 million) in ACH and 4.4 million (95% cCI: 2.0–8.0 million) in LTCF; 3.8 million (95% cCI: 3.1–4.5 million) patients acquired an HAI each year in ACH. Antimicrobial resistance (AMR) to selected AMR markers was 31.6% in ACH and 28.0% in LTCF. Our study confirmed a high annual number of HAI in healthcare facilities in the EU/EEA and indicated that AMR in HAI in LTCF may have reached the same level as in ACH.

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