Excision of Incorporated Nucleotide Analogue Chain-terminators can Diminish their Inhibitory Effects on Viral RNA-dependent RNA Polymerases

2004 ◽  
Vol 337 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Claudia M. D'Abramo ◽  
Luciano Cellai ◽  
Matthias Götte
Keyword(s):  
Rna Polymerases ◽  
Viral Rna ◽  
Inhibitory Effects ◽  
Nucleotide Analogue ◽  
Chain Terminators

scholarly journals Halting coronavirus polymerase

2020 ◽  
Vol 295 (15) ◽  
pp. 4780-4781 ◽  
Author(s):  
Robert N. Kirchdoerfer
Keyword(s):  
Rna Polymerases ◽  
Viral Rna ◽  
Investigational Drug ◽  
Human Coronavirus ◽  
Nucleotide Analogue ◽  
Coronavirus Infection ◽  
Chain Terminator

The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.

Fluorescent primer-based in vitro transcription system of viral RNA-dependent RNA polymerases

2013 ◽  
Vol 433 (2) ◽  
pp. 92-94
Author(s):  
Qiang Wang ◽  
Leiyun Weng ◽  
Hongbing Jiang ◽  
Shijian Zhang ◽  
Tetsuya Toyoda
Keyword(s):  
In Vitro Transcription ◽  
Rna Polymerases ◽  
Viral Rna ◽  
Transcription System

scholarly journals The Palm Subdomain-based Active Site is Internally Permuted in Viral RNA-dependent RNA Polymerases of an Ancient Lineage

2002 ◽  
Vol 324 (1) ◽  
pp. 47-62 ◽  
Author(s):  
Alexander E Gorbalenya ◽  
Fiona M Pringle ◽  
Jean-Louis Zeddam ◽  
Brian T Luke ◽  
Craig E Cameron ◽  
...  
Keyword(s):  
Active Site ◽  
Rna Polymerases ◽  
Viral Rna ◽  
Ancient Lineage

scholarly journals Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays

RNA ◽  
2010 ◽  
Vol 16 (2) ◽  
pp. 382-393 ◽  
Author(s):  
J. F. Spagnolo ◽  
E. Rossignol ◽  
E. Bullitt ◽  
K. Kirkegaard
Keyword(s):  
Rna Polymerases ◽  
Viral Rna

Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases

1990 ◽  
Vol 190 (3) ◽  
pp. 469-476 ◽  
Author(s):  
Katsuhiko ONO ◽  
Hideo NAKANE ◽  
Masanori FUKUSHIMA ◽  
Jean-Claude CHERMANN ◽  
Francoise BARRE-SINOUSSI
Keyword(s):  
Reverse Transcriptase ◽  
Rna Polymerases ◽  
Inhibitory Effects ◽  
Dna And Rna ◽  
Cellular Dna

scholarly journals Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs

2021 ◽  
pp. 315-354
Author(s):  
Kieran Maheden ◽  
Brendan Todd ◽  
Calvin J. Gordon ◽  
Egor P. Tchesnokov ◽  
Matthias Götte
Keyword(s):  
Rna Polymerases ◽  
Viral Rna ◽  
Nucleotide Analogs
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