scholarly journals Phosphorylation of Hepatitis C Virus RNA Polymerases Ser29 and Ser42 by Protein Kinase C-Related Kinase 2 Regulates Viral RNA Replication

2014 ◽  
Vol 88 (19) ◽  
pp. 11240-11252 ◽  
Author(s):  
S.-H. Han ◽  
S.-J. Kim ◽  
E.-J. Kim ◽  
T.-E. Kim ◽  
J.-S. Moon ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Kinase ◽  
Rna Replication ◽  
Rna Polymerases ◽  
Viral Rna ◽  
Hepatitis C Virus Rna ◽  
Kinase C ◽  
Virus Rna

scholarly journals Protein Kinase C-related Kinase 2 Regulates Hepatitis C Virus RNA Polymerase Function by Phosphorylation

2004 ◽  
Vol 279 (48) ◽  
pp. 50031-50041 ◽  
Author(s):  
Seong-Jun Kim ◽  
Jung-Hee Kim ◽  
Yeon-Gu Kim ◽  
Ho-Soo Lim ◽  
Jong-Won Oh
Keyword(s):  
Protein Kinase C ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Kinase ◽  
Rna Polymerase ◽  
Hepatitis C Virus Rna ◽  
Kinase C ◽  
Virus Rna

MATHEMATICAL MODEL FOR SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICATION IN CELL CULTURE

2007 ◽  
Vol 05 (02b) ◽  
pp. 593-609 ◽  
Author(s):  
ELENA L. MISHCHENKO ◽  
KIRILL D. BEZMATERNYKH ◽  
VITALY A. LIKHOSHVAI ◽  
ALEXANDER V. RATUSHNY ◽  
TAMARA M. KHLEBODAROVA ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Replication ◽  
Suppressive Effect ◽  
Viral Rna ◽  
Hepatitis C Virus Rna ◽  
Virus Rna ◽  
Ns3 Protease

A mathematical model for suppression of the hepatitis C virus RNA replicon replication in Huh-7 cell culture in the presence of potential drugs was built. There was a good agreement between the experimental and theoretical kinetic data for the decrease in the level of viral RNA in the cell in the presence of the competitive HCV NS3 protease inhibitor. Using the model, we verified the estimates for the efficiency of the effect of potential drugs on replication of viral RNA and viral protein processing. It was demonstrated that the tested drugs are most efficient at the replication step of viral RNA. The efficiency of the combined action of real and putative inhibitors target on the host and viral proteins was also studied. It was found that the action of the inhibitor at low concentrations on the host factors considerably enhances the suppressive effect on viral RNA replication in the presence of even the low affine NS3 protease inhibitors. The developed mathematical model may serve as a tool for the evaluation of the efficiency of potential drugs on the HCV genome.

Detection and quantification of hepatitis C virus RNA replication in the liver

1994 ◽  
Vol 20 (5) ◽  
pp. 593-597 ◽  
Author(s):  
Naoya Sakamoto ◽  
Nobuyuki Enomoto ◽  
Masayuki Kurosaki ◽  
Fumiaki Marumo ◽  
Chifumi Sato
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Replication ◽  
Hepatitis C Virus Rna ◽  
Virus Rna ◽  
Detection And Quantification

Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase

2005 ◽  
Vol 48 (14) ◽  
pp. 4547-4557 ◽  
Author(s):  
Steven Harper ◽  
Salvatore Avolio ◽  
Barbara Pacini ◽  
Marcello Di Filippo ◽  
Sergio Altamura ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Replication ◽  
Hepatitis C Virus Rna ◽  
Allosteric Inhibitors ◽  
Virus Rna ◽  
Ns5b Polymerase

Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase

Virology ◽  
2019 ◽  
Vol 529 ◽  
pp. 226-233 ◽  
Author(s):  
Ryosuke Suzuki ◽  
Mami Matsuda ◽  
Takashi Shimoike ◽  
Koichi Watashi ◽  
Hideki Aizaki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Kinase ◽  
Rna Polymerase ◽  
Protein Kinase R ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Virus Rna

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture

2009 ◽  
Vol 19 (6) ◽  
pp. 1779-1783 ◽  
Author(s):  
Immacolata Conte ◽  
Claudio Giuliano ◽  
Caterina Ercolani ◽  
Frank Narjes ◽  
Uwe Koch ◽  
...  
Keyword(s):  
Cell Culture ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Replication ◽  
Hepatitis C Virus Rna ◽  
Virus Rna
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