The effect of the CC chemokine receptor antagonist Met-RANTES on experimental autoimmune uveitis and oral tolerance

2005 ◽  
Vol 164 (1-2) ◽  
pp. 22-30 ◽  
Author(s):  
Maria Diedrichs-Möhring ◽  
Peter J. Nelson ◽  
Amanda E.I. Proudfoot ◽  
Stephan R. Thurau ◽  
Gerhild Wildner
Keyword(s):  
Receptor Antagonist ◽  
Chemokine Receptor ◽  
Oral Tolerance ◽  
Experimental Autoimmune Uveitis ◽  
Autoimmune Uveitis ◽  
Cc Chemokine ◽  
Chemokine Receptor Antagonist ◽  
Experimental Autoimmune

scholarly journals Neutrophil-dominant experimental autoimmune uveitis in CC-chemokine receptor 2 knockout mice

2011 ◽  
Vol 89 (2) ◽  
pp. e180-e188 ◽  
Author(s):  
Koh-Hei Sonoda ◽  
Takeru Yoshimura ◽  
Kensuke Egashira ◽  
Israel F. Charo ◽  
Tatsuro Ishibashi
Keyword(s):  
Chemokine Receptor ◽  
Knockout Mice ◽  
Experimental Autoimmune Uveitis ◽  
Autoimmune Uveitis ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 2 ◽  
Experimental Autoimmune

scholarly journals Site-directed Mutagenesis of CC Chemokine Receptor 1 Reveals the Mechanism of Action of UCB 35625, a Small Molecule Chemokine Receptor Antagonist

2004 ◽  
Vol 280 (6) ◽  
pp. 4808-4816 ◽  
Author(s):  
Filipa Lopes de Mendonça ◽  
Paula C. A. da Fonseca ◽  
Rhian M. Phillips ◽  
José W. Saldanha ◽  
Timothy J. Williams ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Small Molecule ◽  
Mechanism Of Action ◽  
Chemokine Receptor ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Cc Chemokine ◽  
Chemokine Receptor Antagonist ◽  
Chemokine Receptor 1

The CC Chemokine Receptor Antagonist Met–RANTES Inhibits Eosinophil Effector Functions

1999 ◽  
Vol 118 (2-4) ◽  
pp. 462-465 ◽  
Author(s):  
Jörn Elsner ◽  
Holger Petering ◽  
Daniela Kimmig ◽  
Timothy N.C. Wells ◽  
Amanda E.J. Proudfoot ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Chemokine Receptor ◽  
Effector Functions ◽  
Cc Chemokine ◽  
Chemokine Receptor Antagonist

Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice

1997 ◽  
Vol 57 (1-3) ◽  
pp. 117-120 ◽  
Author(s):  
Christine Plater-Zyberk ◽  
Arlene J Hoogewerf ◽  
Amanda E.I Proudfoot ◽  
Christine A Power ◽  
Timothy N.C Wells
Keyword(s):  
Receptor Antagonist ◽  
Chemokine Receptor ◽  
Collagen Induced Arthritis ◽  
Cc Chemokine ◽  
Chemokine Receptor Antagonist

scholarly journals TAK-779, A Nonpeptide CC Chemokine Receptor Antagonist, Protects the Brain against Focal Cerebral Ischemia in Mice

2002 ◽  
Vol 22 (7) ◽  
pp. 780-784 ◽  
Author(s):  
Shinya Takami ◽  
Masabumi Minami ◽  
Takahiro Katayama ◽  
Izumi Nagata ◽  
Shobu Namura ◽  
...  
Keyword(s):  
Brain Injury ◽  
Receptor Antagonist ◽  
Chemokine Receptor ◽  
Infarct Volume ◽  
Treated Group ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Cc Chemokine ◽  
Chemokine Receptor Antagonist ◽  
Vehicle Treated Group

The effect of a nonpeptide CC chemokine receptor antagonist, TAK-779, on ischemic brain injury resulting from 1-hour middle cerebral artery occlusion followed by 48-hour reperfusion was examined in ddY mice. On intracerebroventricular injection of vehicle or TAK-779, infarct volume in the vehicle-treated group was 44.2 ± 13.2% of the contralateral hemispheric volume, and TAK-779 (25 and 250 ng/mouse) dose-dependently reduced the infarct volume to 35.0 ± 12.2% and 31.1 ± 12.9%, respectively. On intravenous injection, infarct volume in the vehicle-treated group was 32.0 ± 16.1%, and TAK-779 (5 μg per 20 g body weight) significantly reduced this to 22.0 ± 10.5%. The results showed for the first time that a nonpeptide chemokine receptor antagonist is protective against ischemic brain injury.

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