Cardiovascular complications and its relationship with functional outcome in Guillain–Barre syndrome (GBS)

Introduction: Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis. It carries great morbidity due to an overall high rate of poor functional outcome. This study is conducted to study the predictors of poor functional outcome. Methods: This study a retrospective observational study, which was conducted in Rashid Hospital Tertiary Center in Dubai between 2009 and 2019. Functional status was assessed and followed by the GBS disability score. Functional outcome at 6 months was evaluated for possible predicting factors as well as associated outcomes. Results: Out of the 82 cases, the mean age at presentation is 37 ± 14.4, with 64 (78%) males. Around one-third of cases (37.8%) had residual deficits at 6 months. Follow-up after 6 months showed that cases with a poor functional outcome are older (p = 0.035) and have presented with a high disability score (p < 0.001) and a higher need for mechanical ventilation (p < 0.001). Axonal type of nerve injury resulted in poor functional outcome at 6 months compared to the demyelinating type of nerve injury (p = 0.034). Lower rate of improvement at 1 month and poor functional outcome at 6 months resulted in a longer hospital stay (p < 0.001). Conclusion: A poor functional status at presentation, axonal type of nerve injury, and the early requirement for mechanical ventilation are found to predict poor functional improvement after 6 months from diagnosis. These factors must be kept in consideration to facilitate more vigilant management of patient’s associated high morbidity.

Download Full-text

Heterotopic Ossification in Guillain-Barré Syndrome: Incidence and Effects on Functional Outcome With Long-Term Follow-Up

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2005.07.308 ◽

2006 ◽

Vol 87 (1) ◽

pp. 92-95 ◽

Cited By ~ 10

Author(s):

Gabi Zeilig ◽

Harold P. Weingarden ◽

Richard Levy ◽

Inbal Peer ◽

Avi Ohry ◽

...

Keyword(s):

Functional Outcome ◽

Heterotopic Ossification ◽

Guillain Barre Syndrome ◽

Guillain Barré Syndrome ◽

Long Term Follow Up ◽

Guillain Barré

Download Full-text

Very-early Guillain-Barré syndrome: Clinical characteristics, electrophysiological findings, and short-term functional outcome

Revista Mexicana de Neurociencia ◽

10.24875/rmn.21000024 ◽

2021 ◽

Vol 22 (5) ◽

Author(s):

Juan C. López-Hernández ◽

Raúl N. May-Mas ◽

Javier A. Galnares-Olalde ◽

Lisette Bazán-Rodríguez ◽

Adib J. de-Saráchaga ◽

...

Keyword(s):

Functional Outcome ◽

Clinical Characteristics ◽

Guillain Barre Syndrome ◽

Short Term ◽

Guillain Barré Syndrome ◽

Electrophysiological Findings ◽

Guillain Barré

Download Full-text

Landry-Guillain-Barre Syndrome: Cardiovascular Complications

BMJ ◽

10.1136/bmj.2.4903.1504 ◽

1954 ◽

Vol 2 (4903) ◽

pp. 1504-1507 ◽

Cited By ~ 22

Author(s):

E. Clarke ◽

R. I. S. Bayliss ◽

R. Cooper

Keyword(s):

Cardiovascular Complications ◽

Guillain Barre Syndrome ◽

Guillain Barré Syndrome ◽

Guillain Barré

Download Full-text

Low albumin and pretreatment severity score can predict the functional outcome of Guillain–Barré syndrome

Journal of the Neurological Sciences ◽

10.1016/j.jns.2019.10.856 ◽

2019 ◽

Vol 405 ◽

pp. 48

Author(s):

A. Dyah Kusumawati ◽

I.S.K. Harahap ◽

Y. Yudiyanta

Keyword(s):

Functional Outcome ◽

Severity Score ◽

Guillain Barre Syndrome ◽

Guillain Barré Syndrome ◽

Pretreatment Severity ◽

Guillain Barré

Download Full-text

Cardiovascular complications and its relationship with functional outcomes in Guillain–Barré syndrome

QJM ◽

10.1093/qjmed/hcz225 ◽

2019 ◽

Author(s):

S Gupta ◽

R Verma ◽

R Sethi ◽

R K Garg ◽

H S Malhotra ◽

...

Keyword(s):

Axonal Neuropathy ◽

Univariate Analysis ◽

Cardiovascular Complications ◽

Guillain Barre Syndrome ◽

Neck Muscle ◽

Coronary Syndrome ◽

Number Of Patients ◽

Guillain Barré Syndrome ◽

Poor Outcomes ◽

Guillain Barré

Abstract Background Guillain–Barré syndrome (GBS) is a monophasic disease characterized by acute polyradiculoneuropathy. Aim This study investigated cardiovascular complications in patients with GBS and their relationship with outcomes. Design and methods We included 96 patients, who were diagnosed with GBS according to Brighton case definitions. All enrolled patients were evaluated according to a predetermined algorithm, which included nerve conduction studies, cerebrospinal fluid analysis, electrocardiography, 2D echo, cardiac markers and autonomic function testing. Results We enrolled a total of 96 patients. The mean age of patients was 35.75 ± 17.66 years. Furthermore, 54.2% of patients developed cardiovascular complications, of which changes in electrocardiography (ECG) findings (50%), hypertension (28.12%), labile hypertension (12.5), tachycardia (26.04), bradycardia (13.54%) and a fluctuating heart rate (HR) (11.46) were common. Other cardiovascular complications seen in GBS patients were increased pro-BNP (26.04%), raised troponin T levels (3.12%), acute coronary syndrome (2.08%), heart failure (2.08%) and abnormal 2D echo findings (8.33%). The results of the univariate analysis revealed that a history of preceding infection, a Medical Research Council sum score, neck muscle weakness, facial nerve involvement, bulbar involvement, respiratory failure, cardiovascular complications, autonomic dysfunction, acute motor sensory axonal neuropathy subtype and baseline Hughes score were significantly (P < 0.005) associated with poor outcomes. However, none of these factors were found to be independently associated with poor outcomes in the multivariate analysis. Conclusion A considerable number of patients with GBS developed cardiovascular complications and it needs attention.

Download Full-text