Effect of single nucleotide polymorphisms of the prostacyclin receptor gene on platelet activation in Japanese healthy subjects and patients with cerebral infarction

2013 ◽  
Vol 20 (6) ◽  
pp. 851-856 ◽  
Author(s):  
Mie Shimizu ◽  
Shinichi Yoshimura ◽  
Shunya Takizawa ◽  
Saori Kohara ◽  
Hidetoshi Inoko ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Cerebral Infarction ◽  
Platelet Activation ◽  
Healthy Subjects ◽  
Receptor Gene ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Prostacyclin Receptor

Histamine H3 receptor gene variants associated with drug abuse in patients with cocaine use disorder

2020 ◽  
Vol 34 (11) ◽  
pp. 1326-1330
Author(s):  
Iñigo Pallardo-Fernández ◽  
José Ramón Muñoz-Rodríguez ◽  
Carmen González-Martín ◽  
Luis F Alguacil
Keyword(s):  
Drug Abuse ◽  
Single Nucleotide Polymorphisms ◽  
Receptor Gene ◽  
Gene Variants ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Histamine H3 Receptor ◽  
Cocaine Use ◽  
H3 Receptor ◽  
Histamine H3

Background: Preclinical work revealed significant interactions between ligands of the histamine H3 receptor and different drugs of abuse. In the case of psychostimulants, the results reported are somewhat controversial and human data are still scarce, despite the fact that an inverse agonist of the H3 receptor (pitolisant) has reached the market after approval for the treatment of narcolepsy. Aims: We have studied associations between histamine H3 receptor gene variants and cocaine use disorder to increase the knowledge of the possible involvement of histamine H3 receptor in drug abuse. Methods: Seven single nucleotide polymorphisms of the histamine H3 receptor gene were genotyped by using a multiplexing assay in 248 samples of subjects with cocaine use disorder and 500 randomized samples of subjects representative of the Spanish population. Results: The study of the epidemiological information associated to the samples revealed that subjects with cocaine use disorder broadly abused alcohol, tobacco and cannabinoids. Two single nucleotide polymorphisms (rs3787430 and rs74627870) were found significantly associated with the occurrence of addiction and one more (rs13042865) was specifically related to the severity of cocaine dependence within drug abusers. Conclusions: The associations found in this study further extend the hypothesis that histamine H3 receptor function could be relevant in drug abuse in general and cocaine addiction in particular.

scholarly journals Hyaluronan-Mediated Motility Receptor Gene Single Nucleotide Polymorphisms and Risk of Breast Cancer

2008 ◽  
Vol 17 (12) ◽  
pp. 3618-3620 ◽  
Author(s):  
B. Kalmyrzaev ◽  
P. D.P. Pharoah ◽  
D. F. Easton ◽  
B. A.J. Ponder ◽  
A. M. Dunning ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Receptor Gene ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Single Nucleotide Polymorphisms in the P2X7 Receptor Gene are Associated with Stress Fracture Risk

2014 ◽  
Vol 46 ◽  
pp. 37-38
Author(s):  
Ian Varley ◽  
David C. Hughes ◽  
Julie P. Greeves ◽  
Trent Stellingwerff ◽  
Craig Ranson ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Fracture Risk ◽  
Stress Fracture ◽  
P2x7 Receptor ◽  
Receptor Gene ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Single nucleotide polymorphisms in the apoptosis receptor gene TNFRSF6

2006 ◽  
Vol 20 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Julie E. Niemela ◽  
Amy P. Hsu ◽  
Thomas A. Fleisher ◽  
Jennifer M. Puck
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Receptor Gene ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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