Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Henry T. Shu ◽  
Jacob D. Mikula ◽  
Andrew T. Yu ◽  
Babar Shafiq
Keyword(s):  
Systematic Review ◽  
Tranexamic Acid ◽  
Acetabular Fracture ◽  
Meta Analysis ◽  
Fracture Surgery

scholarly journals Tranexamic acid in hip fracture surgery: A systematic review and meta-analysis

2019 ◽  
Vol 28 (1) ◽  
pp. 230949901988799
Author(s):  
Bashar Haj-Younes ◽  
Brahman S Sivakumar ◽  
Michael Wang ◽  
Vincent VG An ◽  
Peter Lorentzos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hip Fracture ◽  
Blood Transfusion ◽  
Adverse Effects ◽  
Tranexamic Acid ◽  
Meta Analysis ◽  
Small Sample ◽  
Wound Complications ◽  
Hip Fracture Surgery ◽  
Fracture Surgery

Aims: The primary objective of this review was to determine whether tranexamic acid (TXA) reduces transfusion rates in patients undergoing surgery for hip fractures. The secondary objective was to assess the effects of TXA on mortality and thromboembolic events in the same cohort. Methods: A systematic review of electronic databases was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included randomized controlled trials comparing perioperative TXA in patients treated surgically for hip/proximal femoral fractures against placebo. The primary outcome was the proportion of patients requiring blood transfusion. Secondary outcomes were blood loss, mortality, and complications. Meta-analysis was performed using inverse variance and random effects model. Results: The pooled data from 10 studies involving 842 patients showed that the proportion of patients requiring blood transfusion was significantly less in the TXA group (risk ratio (RR) 0.72, 95% confidence interval (CI) 0.59–0.88). There was no difference between TXA and control groups when comparing mortality (RR 1.17, 95% CI 0.65–2.10), deep venous thrombosis (RR 1.14, 95% CI 0.43–3.06), pulmonary embolism (RR 0.53, CI 0.09–3.02), acute coronary syndrome (RR 1.52, CI 0.18–12.98), cerebrovascular events (RR 0.78, CI 0.16–3.68), or wound complications (RR 1.61, CI 0.51–5.13). Conclusion: There is evidence that TXA reduces the proportion of patients requiring blood transfusions when undergoing hip fracture surgery. However, the small sample size and low event rates for adverse effects preclude any definitive conclusions from being established regarding adverse effects. Future trials should be powered to further assess potential complications and determine the ideal dosage and regime.

scholarly journals The efficacy and safety of intravenous tranexamic acid in hip fracture surgery: A systematic review and meta-analysis

2019 ◽  
Vol 19 ◽  
pp. 1-11 ◽  
Author(s):  
Yi-ming Qi ◽  
Hai-peng Wang ◽  
Ying-juan Li ◽  
Bin-bin Ma ◽  
Tian Xie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hip Fracture ◽  
Tranexamic Acid ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Hip Fracture Surgery ◽  
Fracture Surgery

Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Joanna C. Dionne ◽  
Simon JW Oczkowski ◽  
Beverley J. Hunt ◽  
Massimo Antonelli ◽  
Marije Wijnberge ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Tranexamic Acid ◽  
Meta Analysis

Effect of Tranexamic Acid in Subarachnoid Haemorrhage. A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Jean-Baptiste Bouillon-Minois ◽  
Carolyne Croizier ◽  
Julien S. Baker ◽  
Farès Moustafa ◽  
Jeannot Schmidt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Subarachnoid Haemorrhage ◽  
Tranexamic Acid ◽  
Meta Analysis

Systematic review and meta-analysis of the use of tranexamic acid in tonsillectomy

2012 ◽  
Vol 270 (2) ◽  
pp. 735-748 ◽  
Author(s):  
Chee Ching Chan ◽  
Yee Yin Chan ◽  
Faiz Tanweer
Keyword(s):  
Systematic Review ◽  
Tranexamic Acid ◽  
Meta Analysis
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