scholarly journals A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain

2004 ◽  
Vol 28 (1) ◽  
pp. 72-95 ◽  
Author(s):  
Thomas J Schnitzer ◽  
Aimee Ferraro ◽  
Elke Hunsche ◽  
Sheldon X Kong
Keyword(s):  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Efficacy And Safety ◽  
Comprehensive Review

scholarly journals Efficacy and safety of dynamic stabilization for patients with degenerative disc, spinal stenosis and low back pain: a systematic review of randomized controlled clinical trials

2010 ◽  
Vol 9 (3) ◽  
pp. 315-321
Author(s):  
Gustavo Carriço de Oliveira ◽  
Pedro Henrique Lacombe Antoneli
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Spinal Stenosis ◽  
Low Back ◽  
Efficacy And Safety ◽  
Review Of The Literature ◽  
Degenerative Disc ◽  
Randomized Controlled

STUDY DESIGN: Systematic review of the literature. OBJECTIVE: To perform a systematic review of the literature to organize, critical appraisal and select the best evidence available about the efficacy and safety of non-fusion fixation and its potential use for patients with degenerative disc, spinal stenosis and low back pain. SUMMARY OF BACKGROUND DATA: Recent reports have increased debate about the role of dynamic stabilization in the treatment of chronic back pain associated with lumbar disc degeneration and spinal stenosis. We conducted a systematic review of randomized trials through a more sensitivity search strategy and rigorous criteria applied for the type of studies. METHODS: An electronic search was made in the databases of the Cochrane Central Register of Controlled Trials, Medline, Embase, and Latin American and Caribbean Health Sciences (Lilacs) extended to November 31, 2008, with no linguistic restrictions. RESULTS: One randomized controlled trial that fulfilled the inclusion criteria described above was included in this review. CONCLUSION: The data included in this review show that the use of non-fusion stabilization could be a suitable alternative to another therapies in well selected patients with spinal stenosis and degenerative disc disease. This review highlighted the need for continued research into the use of non-fusion stabilization in the treatment of spinal disorders. There is an urgency need to conduct randomized clinical trials. Long-term efficacy should be evaluated.

scholarly journals Efficacy and safety of thread embedding acupuncture combined with conventional acupuncture for chronic low back pain

Medicine ◽  
2018 ◽  
Vol 97 (21) ◽  
pp. e10790 ◽  
Author(s):  
Jungtae Leem ◽  
Hyunho Kim ◽  
Hee-Geun Jo ◽  
Sae-rom Jeon ◽  
Yejin Hong ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Efficacy And Safety

scholarly journals EXTRACORPOREAL SHOCK WAVE THERAPY (ESWT) IN CHRONIC LOW BACK PAIN: A SYSTEMATIC REVIEW OF RANDOMIZED CLINICAL TRIALS

2020 ◽  
Vol 13 (4) ◽  
pp. 1-16
Author(s):  
Karolina Walewicz
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Randomized Clinical Trials ◽  
Extracorporeal Shock Wave Therapy ◽  
Low Back ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave

Background: Extracorporeal Shock Wave Therapy (ESWT) has become a popular tool to treat musculoskeletal disorders and chronic low back pain. Aim of the study: To review the current scientific literature and assess the utility of ESWT in treating chronic low back pain. Methods: This systematic review was conducted from November 2019 to January 2020. Its purpose was to determine what the effectiveness is of the various forms of ESWT for the treatment of chronic low back pain. The critical review of the literature on the use of ESWT in chronic low back was made using the scientifically recognized medical databases PubMed, MEDLINE, Physiotherapy Evidence Database (PEDro) and Web of Science Core Collection. There was no restriction by date. Exclusion criteria were experimental, in vitro, animal, review, case reports, non-randomized clinical trials or studies with healthy participants. All articles written in languages other than English have also been excluded. Results: Six studies were included in the final analysis. According to the applied PEDro classification, the average scoring for the studies was 4.83, which indicates overall low quality of the presented reports. However, this result appeared closer to the moderate (acceptable) quality range (6-8 points) than to the unacceptable range (0-2 points). Conclusion: Based on the findings in the analyzed articles, ESWT promises to be an efficient and useful procedure in chronic low back pain treatment. Unfortunately, the level of evidence is relatively weak because there are a limited number of published studies related to ESWT and the final score in the PEDro classification was low. Together, these results indicate the need for further high quality randomized clinical trials.

scholarly journals Are Older Adults Missing From Low Back Pain Clinical Trials? A Systematic Review and Meta-Analysis

2014 ◽  
Vol 66 (8) ◽  
pp. 1220-1226 ◽  
Author(s):  
Tatjana Paeck ◽  
Manuela L. Ferreira ◽  
Clive Sun ◽  
Chung-Wei Christine Lin ◽  
Anne Tiedemann ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Meta Analysis ◽  
Low Back

Clinical Trials in Low Back Pain

1980 ◽  
Vol 6 (1) ◽  
pp. 143-157
Author(s):  
Rodney Grahame
Keyword(s):  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Low Back

scholarly journals Effectiveness of ozone therapy compared to other therapies for low back pain: a systematic review with meta-analysis of randomized clinical trials

2019 ◽  
Vol 69 (5) ◽  
pp. 493-501 ◽  
Author(s):  
Raul Ribeiro de Andrade ◽  
Olavo Barbosa de Oliveira-Neto ◽  
Luciano Timbó Barbosa ◽  
Isabelle Oliveira Santos ◽  
Célio Fernando de Sousa-Rodrigues ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Low Back ◽  
Ozone Therapy

scholarly journals Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised clinical trial

2020 ◽  
pp. annrheumdis-2020-217259
Author(s):  
Paula Dakin ◽  
Alan J Kivitz ◽  
Joseph S Gimbel ◽  
Nebojsa Skrepnik ◽  
Stephen J DiMartino ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Phase Ii ◽  
Chronic Low Back Pain ◽  
Randomised Clinical Trial ◽  
Controlled Study ◽  
Low Back ◽  
Efficacy And Safety ◽  
Double Blind ◽  
And Function

ObjectivesTo study the efficacy and safety of fasinumab in moderate-to-severe, chronic low back pain (CLBP).MethodsIn this phase II/III, double-blind, placebo-controlled study, patients with CLBP aged ≥35 years with inadequate pain relief/intolerance to acetaminophen, non-steroidal anti-inflammatory drugs and opioids were randomised to fasinumab 6 or 9 mg subcutaneous every 4 weeks (Q4W), 9 mg intravenous every 8 weeks (Q8W) or placebo. Primary endpoint was change from baseline to week 16 in average daily low back pain intensity (LBPI) numeric rating score. Key secondary efficacy variables included Roland-Morris Disability Questionnaire (RMDQ) and Patient Global Assessment (PGA). The results are based on a modified intent-to-treat analysis of 563/800 planned patients when enrolment was stopped early given emerging signals of joint risk in other osteoarthritis (OA) studies at doses being tested here.ResultsSignificant placebo-adjusted LBPI reductions at week 16 were observed for fasinumab 9 mg Q4W and Q8W (least squares mean (standard error) −0.7 (0.3); both nominal p<0.05), but not 6 mg (–0.3 (0.3); p=0.39). RMDQ and PGA improvements to week 16 were greatest for fasinumab 9 mg intravenous. Numerically greater efficacy occurred in patients with, versus those without, peripheral OA (pOA) over 16 weeks. Treatment-emergent adverse events (AEs) occurred in 274/418 (65.6%) patients in the combined fasinumab groups and 94/140 (67.1%) placebo patients. Joint AEs, mostly rapid progressive OA type 1, were more frequent in the combined fasinumab groups (19 events in 16 patients (3.8%) vs 1 event in 1 patient (0.7%) for placebo); all except one occurred in pOA patients.ConclusionsFasinumab highest doses, but not lower dose, improved both CLBP pain and function. Most joint AEs occurred in pOA patients, consistent with earlier findings in symptomatic OA. Further study is needed of patients with CLBP with and without pOA to determine optimal benefit–risk.

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