Role of RET codonic mutations in the surgical management of medullary thyroid carcinoma in pediatric age multiple endocrine neoplasm type 2 syndromes

2010 ◽  
Vol 45 (8) ◽  
pp. 1610-1616 ◽  
Author(s):  
Claudio Spinelli ◽  
Martina Di Giacomo ◽  
Sara Costanzo ◽  
Rossella Elisei ◽  
Paolo Miccoli
2016 ◽  
Vol 12 (4) ◽  
pp. 280-285 ◽  
Author(s):  
Claudio Spinelli ◽  
Silvia Strambi ◽  
Leonardo Rossi ◽  
Rossella Elisei ◽  
Maura Massimino

2013 ◽  
Vol 57 (4) ◽  
pp. 312-316 ◽  
Author(s):  
Pedro Weslley Rosário ◽  
Gustavo Cancela Penna ◽  
Kamilla Brandão ◽  
Bárbara Érika Souza

OBJECTIVE: To evaluate the usefulness of preoperative serum calcitonin (sCT) in patients with nodular disease without suspicion of medullary thyroid carcinoma (MTC) in history or cytology. PATIENTS AND METHODS: sCT was measured before thyroidectomy in 494 patients with nodular disease who had no family history of MTC or multiple endocrine neoplasia type 2, and no cytological suspicion of MTC. RESULTS: Basal sCT was < 10 ng/mL in 482 patients and none of them had MTC. One patient with basal sCT > 100 pg/mL had MTC. Among the 11 patients with basal sCT between 10 and 100 pg/mL, MTC was diagnosed in only one. The two patients with MTC were submitted to total thyroidectomy, combined with elective lymph node dissection indicated exclusively based on hypercalcitoninemia, and sCT was undetectable after six months. CONCLUSIONS: Preoperative sCT is useful for the detection of sporadic MTC in patients with nodular disease, even in the absence of suspicious history or cytology.


1999 ◽  
Vol 20 (4) ◽  
pp. 398
Author(s):  
D. L. Learoyd ◽  
P. J. Roach ◽  
G. M. Snowdon ◽  
K. Dadachova ◽  
A. M. Moreau ◽  
...  

2011 ◽  
Author(s):  
Renata Jaskula-Sztul ◽  
Jacob Eide ◽  
Muthusamy Kunnimalaiyaan ◽  
Herbert Chen

2019 ◽  
Vol 8 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Else Marie Opsahl ◽  
Lars Andreas Akslen ◽  
Ellen Schlichting ◽  
Turid Aas ◽  
Katrin Brauckhoff ◽  
...  

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