A rare case of ovarian juvenile granulosa cell tumor without precocious pseudopuberty in an 11-month-old infant

Granulose cell tumors represent 2% of ovarian tumors. They are classified as adult type and juvenile type. The juvenile type is associated with precocious pseudopuberty, irregular menstruation or nonspecific symptoms such as abdominal pain and palpable mass. More than 95% are confined to the ovary. A case of a 31-year-old patient is described. The patient consulted for 6-month evolution of increased abdominal volume and weight loss. Right ovary tumor was diagnosed. Tumor excision by gynecological laparotomy with positive frozen cut biopsy and surgical staging were performed. Pathological anatomy reported stromal tumor, and sexual cords suggestive of malignant juvenile granulose cell tumor. Immunohistochemistry reported positive inhibin B. It was concluded as stage IIIA2. This is a rare neoplasm with variable behavior. Accurate diagnosis is based on histological and immunohistochemical studies. Key words: Granulosa, Cell tumor, Juvenile granulosa cell tumor, Ascites, Diagnosis.

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Juvenile Granulosa Cell Tumor of the Testis in a Newborn with Swelling in the Scrotum: A Rare Case and Literature Review

Erciyes Medical Journal ◽

10.5152/etd.2017.17016 ◽

2017 ◽

Vol 39 (2) ◽

pp. 78-82 ◽

Cited By ~ 1

Author(s):

Tugay Tartar ◽

Mehmet Sarac ◽

Unal Bakal ◽

Senay Canpolat ◽

Ahmet Kazez

Keyword(s):

Literature Review ◽

Granulosa Cell ◽

Rare Case ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Juvenile Granulosa Cell Tumor

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Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases.

Journal of Clinical Oncology ◽

10.1200/jco.1988.6.6.990 ◽

1988 ◽

Vol 6 (6) ◽

pp. 990-995 ◽

Cited By ~ 65

Author(s):

G Vassal ◽

F Flamant ◽

J M Caillaud ◽

F Demeocq ◽

C Nihoul-Fekete ◽

...

Keyword(s):

Granulosa Cell ◽

Recurrent Disease ◽

Stage Iv ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Pediatric Department ◽

One Stage ◽

Juvenile Granulosa Cell Tumor ◽

Precocious Pseudopuberty

Juvenile granulosa cell tumor (JGCT) in children accounted for 12% of all ovarian tumors treated in the Institut Gustave-Roussy (IGR) Pediatric Department from 1967 to 1985. The median age of the 15 girls was 8 years 7 months (range, 22 months to 15 years 7 months). Precocious pseudopuberty was present in six of the seven girls under 8 years. Of the other seven girls, one developed virilization symptoms. Surgery was the first treatment in each case. According to the Wollner classification, there were six stage I, one stage II, six stage III (including four ruptured tumors), and one stage IV JGCT cases. One patient was not available for staging. An adjuvant treatment (five chemotherapy and one radiotherapy combined with chemotherapy) was administered to six patients. Eleven girls are alive and free of disease, with a median follow-up of 6 years (range, 2 to 18 years). Four girls relapsed 6 to 17 months after surgery and died. Two of these relapses occurred in bone. The prognosis for JGCT in children is favorable for the lower stages when treated with surgery, but the best treatment for extensive and recurrent disease has yet to be determined.

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