scholarly journals The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia

2015 ◽  
Vol 128 (2) ◽  
pp. 65-70 ◽  
Author(s):  
Tomonori Yamanishi ◽  
Kanya Kaga ◽  
Miki Fuse ◽  
Chiharu Shibata ◽  
Takao Kamai ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Muscarinic Receptor ◽  
Prostatic Hyperplasia ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
Overactive Detrusor ◽  
Normal Human ◽  
Human Detrusor

Role of Muscarinic Receptor Subtypes in the Constriction of Peripheral Airways: Studies on Receptor-Deficient Mice

2003 ◽  
Vol 64 (6) ◽  
pp. 1444-1451 ◽  
Author(s):  
Nicole Struckmann ◽  
Sandra Schwering ◽  
Silke Wiegand ◽  
Anja Gschnell ◽  
Masahisa Yamada ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
Peripheral Airways ◽  
Deficient Mice

Development of ovine fetal ileal motility: role of muscarinic receptor subtypes

2003 ◽  
Vol 189 (4) ◽  
pp. 953-957 ◽  
Author(s):  
Noboru Oyachi ◽  
Jayaraman Lakshmanan ◽  
Sureshbabu N Ahanya ◽  
Daryoush Bassiri ◽  
James B Atkinson ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
Ovine Fetal ◽  
Ileal Motility

scholarly journals Role of muscarinic receptor subtypes in central antinociception

1992 ◽  
Vol 105 (1) ◽  
pp. 77-82 ◽  
Author(s):  
A. Bartolini ◽  
C. Ghelardini ◽  
L. Fantetti ◽  
M. Malcangio ◽  
P. Malmberg-Aiello ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes

Role of hippocampal M1 and M4 muscarinic receptor subtypes in memory consolidation in the rat

2003 ◽  
Vol 74 (2) ◽  
pp. 411-415 ◽  
Author(s):  
Amâncio Romanelli Ferreira ◽  
Lucas Fürstenau ◽  
Carlos Blanco ◽  
Edgar Kornisiuk ◽  
Gonzalo Sánchez ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Memory Consolidation ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
M4 Muscarinic Receptor

Characterization of muscarinic receptor subtypes on human peripheral lung

1988 ◽  
Vol 65 (2) ◽  
pp. 594-600 ◽  
Author(s):  
T. B. Casale ◽  
P. Ecklund
Keyword(s):  
Muscarinic Receptor ◽  
Muscarinic Receptors ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
High Affinity ◽  
Airway Diseases ◽  
Kd Values ◽  
Peripheral Lung

To better define the role of muscarinic receptors in lung responses and airway diseases, we characterized the binding of the M1-specific antagonist, [3H]pirenzepine (PZ), and the nonspecific (M1- and M2-) antagonist, [3H]quinuclidinyl benzilate (QNB), to human peripheral lung tissue. Data obtained from 15 different lung specimens showed that the radioligands bound to single high-affinity sites with dissociation constant (Kd) values ranging from 1 to 9 nM for [3H]PZ and 0.03 to 0.46 nM for [3H]QNB. Comparison of total binding capacity values by equilibrium experiments with [3H]PZ, unlabeled PZ, and [3H]QNB indicates that approximately one-half of the total muscarinic binding sites in human peripheral lung binds PZ with high affinity (putative M1-subtypes). Kd values for muscarinic agents determined by competition experiments with [3H]PZ were consistent with the expected rank order of potency for interactions with muscarinic receptors. Characterization of the role of these muscarinic receptor subtypes in human lung responses may lead to the development of more selective therapeutic agents for the treatment of chronic obstructive airway diseases.

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