Serotonin transporter (5-HTTLPR) polymorphism and psychosocial variables related to post-traumatic stress symptoms in breast cancer patients

2018 ◽  
Vol 109 ◽  
pp. 106
Author(s):  
L. Grassi ◽  
M.G. Nanni ◽  
W. Lam ◽  
M. Rubini ◽  
G. Piazza ◽  
...  
2021 ◽  
Vol 12 ◽  
Author(s):  
Luigi Zerbinati ◽  
Martino Belvederi Murri ◽  
Rosangela Caruso ◽  
Maria Giulia Nanni ◽  
Wendy Lam ◽  
...  

Introduction: Post-traumatic Symptoms (PTSS) and Post-traumatic Stress Disorder (PTSD) have been reported to affect a quite significant proportion of cancer patients. No study has examined the relationship between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cancer, including Gene-Environment interactions between this polymorphism and specific causes of distress, such as cancer related problems (CRP) or life stressful events (SLE).Methods: One hundred and forty five breast cancer outpatients participated in the study and were assessed using the Impact of Event Scale (IES), the Problem List (PL) developed by the National Comprehensive Cancer Network (NCCN) Distress Management Guidelines and the Paykel's Life Events Interview to evaluate the exposure to SLE during the year before the cancer diagnosis. Each patient was genotyped for 5-HTTLPR polymorphism by analyzing genomic DNA obtained from whole blood cells. Gene-Environment interactions were tested through moderation analysis.Results: Twenty-six patients (17.7%) were classified as PTSS cases using the IES. Genotype and phenotype distributions did not differ across individuals with/without PTSS (genotype: χ2 = 1.5; df = 2; p = 0.3; phenotype χ2 = 0.9; df = 1; p = 0.2). For both the genotype and phenotype model, using CRP as a predictor showed significant gene-environment interactions with IES total score (p = 0.020 and p = 0.004, respectively), with individuals carrying the l/l allele showing a greater probability of experiencing PTSS. No interaction was found in relationship to SLE (p = 0.750).Conclusion: This study showed a significant GEI between CRP and PTSS in breast cancer patients, with carriers of the l/l allele showing indicators consistent with greater sensitivity to stress.


2019 ◽  
Vol 2 (2) ◽  
pp. 29-35 ◽  
Author(s):  
O Zsigmond ◽  
A Vargay ◽  
E Józsa ◽  
É Bányai

Purpose The purpose of this study was to explore the factors influencing post-traumatic growth in breast cancer patients during 3 years after diagnosis. Materials and methods Our longitudinal study involved 71 medium and high-risk breast cancer patients, who received special attention and either hypnosis or music psychological intervention while receiving the same chemotherapy protocol. The influences of the interventions, as well as the demographic (age, marital status, and educational level) and psychosocial factors (coping, post-traumatic stress, and well-being), on post-traumatic growth were explored. Results The results showed that over 97% of our patients experienced post-traumatic growth. It was positively associated with Quality of Life domains 3 years after diagnosis, and with Psychological Immune Competence cumulative scores after treatment and 3 years after diagnosis. Psychological Immune Competence, emotional severity of post-traumatic stress symptoms, and the social support scale of Quality of Life explained 33.9% of the variance of post-traumatic growth. Conclusion The results confirm that positive coping strategies, emotional severity of post-traumatic stress symptoms, and social support contribute to post-traumatic growth, and that post-traumatic growth has a weak to moderate association with quality of life.


2016 ◽  
Vol 108 (8) ◽  
pp. djw048 ◽  
Author(s):  
Amir Ali Sepehry ◽  
Scott Tyldesley ◽  
Margot Kathleen Davis ◽  
Christine Simmons ◽  
Alexander Rauscher ◽  
...  

Author(s):  
Kerstin Hermelink ◽  
Markus Bühner ◽  
Philipp Sckopke ◽  
Franziska Neufeld ◽  
Judith Kaste ◽  
...  

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