An INVESTIGATION of the effects of amniotic fluid on experimental ischemia/reperfusion damage in rat testes

2021 ◽  
Author(s):  
Ibrahim Aydogdu ◽  
Erkin Karaca ◽  
Ganime Coban ◽  
Ali Cay ◽  
Eray Metin Guler ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Ischemia Reperfusion ◽  
Reperfusion Damage

Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage

2004 ◽  
Vol 37 (3) ◽  
pp. 149-152 ◽  
Author(s):  
Burhan Ates ◽  
Ismet Yilmaz ◽  
Hikmet Geckil ◽  
Mustafa Iraz ◽  
Mustafa Birincioglu ◽  
...  
Keyword(s):  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Protective Role ◽  
Reperfusion Damage ◽  
Intestinal Ischemia Reperfusion

scholarly journals Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke

2019 ◽  
Vol 28 (9-10) ◽  
pp. 1306-1320 ◽  
Author(s):  
Tatiana Taís Sibov ◽  
Lorena Favaro Pavon ◽  
Francisco Romero Cabral ◽  
Ivone Farias Cunha ◽  
Daniela Mara de Oliveira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Cellular Therapy ◽  
Ischemia Reperfusion Injury ◽  
Focal Cerebral Ischemia ◽  
Infarct Volume ◽  
Ischemia Reperfusion ◽  
Cerebral Injury ◽  
Human Amniotic Fluid ◽  
Severity Scores

Amniotic fluid has been investigated as new cell source for stem cells in the development of future cell-based transplantation. This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia–reperfusion injury in Wistar rats. Middle cerebral artery occlusion of 60 min followed by reperfusion for 1 h, 6 h, and 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in rats. Tests were employed to assess the functional outcome of the sensorimotor center activity in the brain, through a set of modified neurological severity scores used to assess motor and exploratory capacity 24 h, 14, and 28 days after receiving cellular therapy via tail vein. In our animal model of stroke, transplanted cells migrated to the ischemic focus, infarct volume decreased, and motor deficits improved. Therefore, we concluded that these cells appear to have beneficial effects on the ischemic brain, possibly based on their ability to enhance endogenous repair mechanisms.

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