scholarly journals PKD1-Associated Arachnoid Cysts in Autosomal Dominant Polycystic Kidney Disease

2021 ◽  
Vol 30 (9) ◽  
pp. 105943
Author(s):  
Kaori Shigemori ◽  
Eiji Higashihara ◽  
Masayuki Itoh ◽  
Hiroki Yoshida ◽  
Kouji Yamamoto ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Arachnoid Cysts ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

Intracranial cysts in autosomal dominant polycystic kidney disease

1995 ◽  
Vol 83 (6) ◽  
pp. 1004-1007 ◽  
Author(s):  
Wouter I. Schievink ◽  
John Huston ◽  
Vicente E. Torres ◽  
W. Richard Marsh
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Arachnoid Cysts ◽  
Control Group ◽  
Polycystic Kidney ◽  
Content Type ◽  
Intracranial Cysts ◽  
Autosomal Dominant Polycystic Kidney ◽  
Fine Print

✓ Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder well known for its association with intracranial aneurysms. A series of patients with ADPKD who were screened for the presence of an intracranial aneurysm were reviewed and found to include an unexpectedly high number with intracranial arachnoid cysts. Among 247 patients with ADPKD who underwent magnetic resonance imaging (180 cases) or high-resolution contrastenhanced computerized tomography (67 cases), there were 151 women and 96 men with a mean age of 44 years. Intracranial arachnoid cysts were found in 20 patients (8.1%) with ADPKD compared to two (0.8%) in a control group without ADPKD matched for age, sex, and method of imaging (p < 0.0001). Multiple intracranial arachnoid cysts were found in two patients. Polycystic liver disease was present in 17 (85.0%) of the 20 patients with intracranial arachnoid cysts compared to 119 (52.4%) of the 227 patients without (p < 0.004). Pineal cysts were found in two patients (0.8%) and choroid plexus cysts were found in three patients (1.2%) but this was not different from the control population. None of the intracranial cysts was symptomatic and none was treated surgically. Intracranial arachnoid cysts are a relatively frequent incidental finding in patients with ADPKD, providing further support for the systemic nature of this disease. In the authors' experience with approximately 1500 patients with ADPKD, no complication has been encountered from an intracranial arachnoid cyst, suggesting that asymptomatic intracranial arachnoid cysts in patients with ADPKD require no treatment.

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