The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer

Background In the eighth edition of the TNM classification, the lung tumors that have the same solid components are categorized either as part-solid or pure-solid tumors. However, this is debatable since the tumors in the same T component categories were evaluated without considering this categorization, and was based on a more malignant behavior and a poorer prognosis of pure-solid tumors. The aim of this study was to investigate and compare the prognosis between part-solid and pure-solid tumors. Methods We retrospectively analyzed 530 patients who were diagnosed with clinical-T1a-cN0M0 non–small-cell lung cancer (NSCLC) and were treated surgically. The subjects were divided into part-solid and pure-solid tumor groups using thin-section computed tomography. The prognosis was compared between the groups. Results Although relapse-free survival (RFS) was significantly shorter in the pure-solid tumor group (p = 0.016), no significant differences were observed in the overall survival (OS) between the two groups (p = 0.247). In 137 propensity score–matched pairs, including variables such as age, gender, Brinkman index, body mass index, forced expiratory volume in 1 second/forced vital capacity, Charlson comorbidity index, carcinoembryonic antigen levels, clinical-T status, surgical procedure, and extent of surgery, no significant differences were seen in the RFS and OS between the two groups (p = 0.709 and p = 0.517, respectively). Conclusion In the eighth edition of the TNM classification of clinical-T1a-cN0M0 NSCLC, the prognosis of part-solid and pure-solid tumors showed no significant differences. Solid component size of the tumor is considered important prognostic factor in early-stage NSCLC.

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The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2015.12.114 ◽

2016 ◽

Vol 11 (5) ◽

pp. 681-692 ◽

Cited By ~ 56

Author(s):

Frank C. Detterbeck ◽

Vanessa Bolejack ◽

Douglas A. Arenberg ◽

John Crowley ◽

Jessica S. Donington ◽

...

Keyword(s):

Lung Cancer ◽

Tnm Classification ◽

Cancer Staging ◽

Background Data ◽

Eighth Edition

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The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer

Journal of Thoracic Oncology ◽

10.1097/jto.0000000000000559 ◽

2015 ◽

Vol 10 (7) ◽

pp. 990-1003 ◽

Cited By ~ 304

Author(s):

Ramón Rami-Porta ◽

Vanessa Bolejack ◽

John Crowley ◽

David Ball ◽

Jhingook Kim ◽

...

Keyword(s):

Lung Cancer ◽

Tnm Classification ◽

Cancer Staging ◽

Eighth Edition

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A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition)

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyz052 ◽

2019 ◽

Vol 49 (7) ◽

pp. 589-595 ◽

Cited By ~ 2

Author(s):

◽

Nobuya Monden ◽

Takahiro Asakage ◽

Naomi Kiyota ◽

Akihiro Homma ◽

...

Keyword(s):

Head And Neck ◽

Malignant Tumors ◽

Tnm Classification ◽

Cancer Control ◽

Cancer Staging ◽

Unknown Primary ◽

Oropharyngeal Carcinoma ◽

Depth Of Invasion ◽

Eighth Edition

Abstract A number of major modifications were made to the classification of head and neck carcinomas in the eighth edition of the American Joint Committee on Cancer, Cancer Staging Manual and Union for International Cancer Control TNM classification of Malignant Tumors. These modifications were aimed at improving the prognosis prediction accuracy of the system. In this article, we review the new edition of the TNM classification system. Among the several changes in the new system, a separate algorithm for p16-positive oropharyngeal carcinoma was included, as were new chapters on ‘Head and Neck Skin Carcinoma’ and ‘Unknown Primary Carcinoma—Cervical Nodes.’ Changes to Tumor (T) classification were made by introducing the depth of invasion of oral carcinoma, whereas changes to Node (N) classification were made by adding extra-nodal extension. It is believed that these changes will help improve the accuracy of the system in the prediction of prognosis. However, it is necessary to verify their validity through further clinical research.

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