MP31-10 ADDITIVE CONTRACTIONS BY THROMBOXANE A2 AND ENDOTHELIN-1 ARE STRONGER THAN NOREPINEPHRINE-INDUCED CONTRACTIONS IN HUMAN PROSTATE SMOOTH MUSCLE

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Martin Hennenberg ◽  
Alice C. Acevedo ◽  
Alexander Tamalunas ◽  
Yiming Wang ◽  
Beata Rutz ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Thromboxane A2 ◽  
Human Prostate ◽  
Endothelin 1

896 Additive contractions by thromboxane A2 and endothelin-1 are stronger than norepinephrineinduced contractions in human prostate smooth muscle

2015 ◽  
Vol 14 (2) ◽  
pp. e896
Author(s):  
M. Hennenberg ◽  
A.C. Acevedo ◽  
Y. Wang ◽  
B. Rutz ◽  
F. Strittmatter ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Thromboxane A2 ◽  
Human Prostate ◽  
Endothelin 1

Effects of the receptor antagonist picotamide on endothelin-1-, -2- and -3-induced contractions in human prostate smooth muscle

2017 ◽  
Vol 16 (3) ◽  
pp. e186
Author(s):  
M. Hennenberg ◽  
A. Tamalunas ◽  
F. Strittmatter ◽  
C. Stief ◽  
C. Gratzke
Keyword(s):  
Smooth Muscle ◽  
Receptor Antagonist ◽  
Human Prostate ◽  
Endothelin 1

Thromboxane A2 induces contraction of human prostate smooth muscle by Rho kinase- and calmodulin-dependent mechanisms

2011 ◽  
Vol 650 (2-3) ◽  
pp. 650-655 ◽  
Author(s):  
Frank Strittmatter ◽  
Christian Gratzke ◽  
Philipp Weinhold ◽  
Christian J. Steib ◽  
Anna C. Hartmann ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Rho Kinase ◽  
Thromboxane A2 ◽  
Human Prostate

scholarly journals MP44-13 EFFECTS OF THE RECEPTOR ANTAGONIST PICOTAMIDE ON ENDOTHELIN-1-, -2- AND -3-INDUCED CONTRACTIONS IN HUMAN PROSTATE SMOOTH MUSCLE

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Alexander Tamalunas ◽  
Christian Gratzke ◽  
Frank Strittmatter ◽  
Raphaela Waidelich ◽  
Christian Stief ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Receptor Antagonist ◽  
Human Prostate ◽  
Endothelin 1

Effect of Ridogrel on Vascular Contractions Gaused by Vasoactive Substances Released during Platelet Activation

1990 ◽  
Vol 64 (01) ◽  
pp. 091-096 ◽  
Author(s):  
W J Janssens ◽  
F J S Cools ◽  
L A M Hoskens ◽  
J M Van Nueten
Keyword(s):  
Smooth Muscle ◽  
Blood Vessel ◽  
Platelet Activation ◽  
Prostaglandin F2α ◽  
Thromboxane A2 ◽  
Femoral Arteries ◽  
Vasoactive Substances ◽  
Caudal Artery ◽  
Isolated Rat ◽  
Rat Platelets

SummaryRidogrel (6.3 × 10−6 to 10−4 M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 × 10−6 M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within}D min of incubation of the blood vessel with the compound and easily reversible. Ridogrel antagonised contractions of isolated rabbit femoral arteries caused by prostaglandin Fzo2α in the same concentration range. Ridogrel also inhibited contractions induced by aggregating rat platelets on isolated rat caudal arteries (itt the presence of ketanserin 4 × 10−7 M) and on isolated rabbit pulmonary and femoral arteries (in the absence of ketanserin). Ridogrel had no effect on Ca2+-induced contractions in depolarised isolated rabbit femoral arteries, and at 10−4 M antagonised serotonin-induced contractions in this blood vessel. Its effect on serotonin-induced contractions was statistically significant but very small on isolated rat caudal arteries. These observations indicate that ridogrel is an antagonist of prostaglandin endoperoxide/thromboxane A2 and prostaglandin F2α raCeptors on vascular smooth muscle.

Endothelin-1 Enhances Nitric Oxide–Induced Cytotoxicity in Vascular Smooth Muscle

Hypertension ◽  
1995 ◽  
Vol 25 (4) ◽  
pp. 744-747 ◽  
Author(s):  
Takeshi Nakahashi ◽  
Keisuke Fukuo ◽  
Takuo Inoue ◽  
Shigeto Morimoto ◽  
Shigeki Hata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Endothelin 1

Effects of Histamine and Endothelin-1 on Membrane Potentials and Ion Currents in Bovine Tracheal Smooth-Muscle Cells

1998 ◽  
Vol 19 (5) ◽  
pp. 805-811 ◽  
Author(s):  
Masayuki Nara ◽  
Tsukasa Sasaki ◽  
Sanae Shimura ◽  
Takako Oshiro ◽  
Toshiya Irokawa ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Membrane Potentials ◽  
Tracheal Smooth Muscle ◽  
Ion Currents ◽  
Endothelin 1
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