Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident—With focus on immunoglobulin heavy chain gene analysis

2008 ◽  
Vol 32 (4) ◽  
pp. 535-545 ◽  
Author(s):  
Iryna Abramenko ◽  
Nadia Bilous ◽  
Anatoliy Chumak ◽  
Ekaterina Davidova ◽  
Iryna Kryachok ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Ionizing Radiation ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Lymphocytic Leukemia ◽  
Gene Analysis ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Chernobyl Npp

scholarly journals The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene

Blood ◽  
1989 ◽  
Vol 73 (8) ◽  
pp. 2081-2085 ◽  
Author(s):  
JC Grimaldi ◽  
TC Meeker
Keyword(s):  
Heavy Chain ◽  
Acute Lymphocytic Leukemia ◽  
Chromosomal Translocation ◽  
Immunoglobulin Heavy Chain ◽  
Lymphocytic Leukemia ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Interleukin 3 ◽  
Chromosomal Breakpoints

Abstract Chromosomal translocations have proven to be important markers of the genetic abnormalities central to the pathogenesis of cancer. By cloning chromosomal breakpoints one can identify activated proto-oncogenes. We have studied a case of B-lineage acute lymphocytic leukemia (ALL) that was associated with peripheral blood eosinophilia. The chromosomal translocation t(5;14) (q31;q32) from this sample was cloned and studied at the molecular level. This translocation joined the immunoglobulin heavy chain joining (Jh) region to the promotor region of the interleukin-3 (IL-3) gene in opposite transcriptional orientations. The data suggest that activation of the IL-3 gene by the enhancer of the immunoglobulin heavy chain gene may play a central role in the pathogenesis of this leukemia and the associated eosinophilia.

scholarly journals Immunoglobulin Heavy Chain Gene Analysis in Lymphomas

2002 ◽  
Vol 4 (2) ◽  
pp. 81-89 ◽  
Author(s):  
Adam Bagg ◽  
Rita M. Braziel ◽  
Daniel A. Arber ◽  
Karen E. Bijwaard ◽  
Albert Y. Chu
Keyword(s):  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Gene Analysis ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene

scholarly journals The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene

Blood ◽  
1989 ◽  
Vol 73 (8) ◽  
pp. 2081-2085 ◽  
Author(s):  
JC Grimaldi ◽  
TC Meeker
Keyword(s):  
Heavy Chain ◽  
Acute Lymphocytic Leukemia ◽  
Chromosomal Translocation ◽  
Immunoglobulin Heavy Chain ◽  
Lymphocytic Leukemia ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Interleukin 3 ◽  
Chromosomal Breakpoints

Chromosomal translocations have proven to be important markers of the genetic abnormalities central to the pathogenesis of cancer. By cloning chromosomal breakpoints one can identify activated proto-oncogenes. We have studied a case of B-lineage acute lymphocytic leukemia (ALL) that was associated with peripheral blood eosinophilia. The chromosomal translocation t(5;14) (q31;q32) from this sample was cloned and studied at the molecular level. This translocation joined the immunoglobulin heavy chain joining (Jh) region to the promotor region of the interleukin-3 (IL-3) gene in opposite transcriptional orientations. The data suggest that activation of the IL-3 gene by the enhancer of the immunoglobulin heavy chain gene may play a central role in the pathogenesis of this leukemia and the associated eosinophilia.

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