Development of radioligands with optimized imaging properties for quantification of nicotinic acetylcholine receptors by positron emission tomography

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Positron Emission ◽

Imaging Properties

LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[18F]Flubatine—A Positron Emission Tomography Radioligand for Imaging α4β2 Nicotinic Acetylcholine Receptors

Molecules ◽

10.3390/molecules21091200 ◽

2016 ◽

Vol 21 (9) ◽

pp. 1200 ◽

Cited By ~ 7

Author(s):

Friedrich-Alexander Ludwig ◽

René Smits ◽

Steffen Fischer ◽

Cornelius Donat ◽

Alexander Hoepping ◽

...

Keyword(s):

Acetylcholine Receptors ◽

In Vitro Metabolism ◽

Emission Tomography ◽

In Vivo Metabolism ◽

Nicotinic Acetylcholine ◽

Synthesis and evaluation of new radioligands [11C]A-833834 and [11C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2012.11.013 ◽

2013 ◽

Vol 40 (3) ◽

pp. 395-402 ◽

Cited By ~ 13

Author(s):

Andrew G. Horti ◽

Hayden T. Ravert ◽

Yongjun Gao ◽

Daniel P. Holt ◽

William H. Bunnelle ◽

...

Keyword(s):

Α7 Nicotinic Acetylcholine Receptors

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Positron Emission ◽

Synthesis and Evaluation of a Novel Series of 2-Chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine Analogues as Potential Positron Emission Tomography Imaging Agents for Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm010550n ◽

2002 ◽

Vol 45 (13) ◽

pp. 2841-2849 ◽

Cited By ~ 18

Author(s):

LaVerne L. Brown ◽

Santosh Kulkarni ◽

Olga A. Pavlova ◽

Andrei O. Koren ◽

Alexey G. Mukhin ◽

...

Keyword(s):

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Imaging Agents ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Vinyl Pyridine

Cerebral nicotinic acetylcholine receptors in patients with Alzheimer's disease or vascular dementia - evaluation with 2-[18F]F-A85380 and positron emission tomography (PET)

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0580 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S580-S580

Author(s):

Kai Kendziorra ◽

Philipp Meyer ◽

Henryk Barthel ◽

Georg Becker ◽

Dietlind Sorger ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Vascular Dementia ◽

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Radiosynthesis and evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[11CH3]methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogs, high affinity ligands for studying nicotinic acetylcholine receptors by positron emission tomography

Journal of Labelled Compounds and Radiopharmaceuticals ◽

10.1002/jlcr.2580440104 ◽

2001 ◽

Vol 44 (S1) ◽

pp. S9-S11

Author(s):

L. L. Brown ◽

A. G. Mukhin ◽

S. I. Chefer ◽

O. Pavlova ◽

A. O. Koren ◽

...

Keyword(s):

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Affinity Ligands ◽

High Affinity ◽

Derivatives of Dibenzothiophene for Positron Emission Tomography Imaging of α7-Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm401184f ◽

2013 ◽

Vol 56 (19) ◽

pp. 7574-7589 ◽

Cited By ~ 36

Author(s):

Yongjun Gao ◽

Kenneth J. Kellar ◽

Robert P. Yasuda ◽

Thao Tran ◽

Yingxian Xiao ◽

...

Keyword(s):

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Derivatives Of

Pharmacological and Toxicological Evaluation of 2-Fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a Ligand for Imaging Cerebral Nicotinic Acetylcholine Receptors with Positron Emission Tomography

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.073999 ◽

2004 ◽

Vol 312 (1) ◽

pp. 355-365 ◽

Cited By ~ 22

Author(s):

D. Bruce Vaupel ◽

Srihari R. Tella ◽

David L. Huso ◽

Valentine O. Wagner ◽

Alexey G. Mukhin ◽

...

Keyword(s):

Acetylcholine Receptors ◽

Emission Tomography ◽

Toxicological Evaluation ◽

Nicotinic Acetylcholine ◽

Development of Radioligands for the Imaging of ?7 Nicotinic Acetylcholine Receptors with Positron Emission Tomography

Current Drug Targets ◽

10.2174/138945012800398955 ◽

2012 ◽

Vol 13 (5) ◽

pp. 594-601 ◽

Cited By ~ 21

Author(s):

Peter Brust ◽

Dan Peters ◽

Winnie Deuther-Conrad

Keyword(s):

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Derivatives of (−)-7-Methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane Are Potential Ligands for Positron Emission Tomography Imaging of Extrathalamic Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/jm070224t ◽

2007 ◽

Vol 50 (16) ◽

pp. 3814-3824 ◽

Cited By ~ 8

Author(s):

Yongjun Gao ◽

Andrew G. Horti ◽

Hiroto Kuwabara ◽

Hayden T. Ravert ◽

John Hilton ◽

...

Keyword(s):

Acetylcholine Receptors ◽

Positron Emission Tomography Imaging ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Tomography Imaging ◽

Positron Emission ◽

Derivatives Of

Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[ 11 C]methyl-2-( S )-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomography

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(01)00224-3 ◽

2001 ◽

Vol 9 (11) ◽

pp. 3055-3058 ◽

Cited By ~ 6

Author(s):

LaVerne L. Brown ◽

Olga Pavlova ◽

Alexey Mukhin ◽

Alane S. Kimes ◽

Andrew G. Horti

Keyword(s):

Acetylcholine Receptors ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

High Affinity ◽

Affinity Ligand ◽

Positron Emission ◽

High Affinity Ligand