Antiphospholipid Syndrome-induced Ischemic Stroke Following Pembrolizumab: case report and systematic review

Objective The purpose of this study was to characterize the role of eculizumab, a monoclonal antibody against the terminal complement component C5, in patients with catastrophic antiphospholipid syndrome (CAPS). Methods We present a case report of a patient with systemic lupus erythematosus (SLE) and CAPS treated with eculizumab, as well as results of a systematic review of the literature. Results Including our patient, we identified 11 case reports of patients with CAPS treated with eculizumab. All of them had partial or total remission of symptoms. Conclusion Data on eculizumab efficacy in CAPS are promising but are limited to single case reports. More studies are needed to develop evidence-based recommendations for eculizumab use in CAPS.

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Aortic thrombosis: the forgotten source of ischemic stroke. A case report and systematic review of the literature

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2021.2090 ◽

2021 ◽

Author(s):

Christian Basile ◽

Costantino Mancusi ◽

Paola Gargiulo ◽

Pasquale Perrone Filardi ◽

Cinzia Perrino ◽

...

Keyword(s):

Systematic Review ◽

Ischemic Stroke ◽

Case Report ◽

Acute Ischemic Stroke ◽

Economic Impact ◽

Industrialized Countries ◽

Review Of The Literature ◽

Aortic Thrombosis ◽

Important Health ◽

Socio Economic Impact

Ischemic stroke represents one of the most important health problems in industrialized countries, both for epidemiological and socio-economic impact. The presence of thrombi in the aorta is rare and its treatment has not been uniquely defined. Here we report the case of an 82-years-old man with aortic thrombosis and acute ischemic stroke.

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Eculizumab in refractory catastrophic antiphospholipid syndrome: a case report and systematic review of the literature

Clinical and Experimental Medicine ◽

10.1007/s10238-019-00565-8 ◽

2019 ◽

Vol 19 (3) ◽

pp. 281-288 ◽

Cited By ~ 12

Author(s):

Maria Giulia Tinti ◽

Vincenzo Carnevale ◽

Michele Inglese ◽

Francesca Molinaro ◽

Marco Bernal ◽

...

Keyword(s):

Systematic Review ◽

Case Report ◽

Antiphospholipid Syndrome ◽

Review Of The Literature ◽

Catastrophic Antiphospholipid Syndrome

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Case Report: Infantile Ischemic Stroke and Antiphospholipid Antibodies, Description of Four Cases

Frontiers in Pediatrics ◽

10.3389/fped.2020.596386 ◽

2020 ◽

Vol 8 ◽

Author(s):

Teresa Giani ◽

Angela Mauro ◽

Giovanna Ferrara ◽

Rolando Cimaz

Keyword(s):

Ischemic Stroke ◽

Case Report ◽

Autoimmune Disease ◽

Antiphospholipid Syndrome ◽

Antiphospholipid Antibodies ◽

De Novo ◽

Rare Condition ◽

Gray Zone ◽

Transplacental Passage ◽

Perinatal Stroke

Antiphospholipid syndrome (APS) is a rare condition in childhood, but even more in the neonatal age. Most neonatal cases are considered a passively acquired autoimmune disease, due to a transplacental passage of maternal antiphospholipid antibodies (aPL) from mothers with primary or secondary APS or, more often, from asymptomatic aPL carriers. Exceedingly unusual is the neonatal de novo production of aPL. We present four infants with presumed perinatal stroke in presence of increased and persistent aPL levels, even after 6 months of life, opening the window on a gray zone related to the origin of these antibodies (maternal or neonatal) and on their role in the pathogenesis of stroke.

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Anticoagulation Strategies for Treatment of Ischemic Stroke and Antiphospholipid Syndrome: Case Report and Review of the Literature

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy ◽

10.1592/phco.26.10.1518 ◽

2006 ◽

Vol 26 (10) ◽

pp. 1518-1525 ◽

Cited By ~ 3

Author(s):

Shawnna L Patterson ◽

Marian P LaMonte ◽

Jamal A Mikdashi ◽

Stuart T Haines ◽

Marcie J Hursting

Keyword(s):

Ischemic Stroke ◽

Case Report ◽

Antiphospholipid Syndrome ◽

Review Of The Literature

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Acute limb ischemia in a patient with pre-fibrotic myelofibrosis complicated by heparin-induced thrombocytopenia and thrombosis – case report and systematic review of dabigatran use

VASA ◽

10.1024/0301-1526/a000876 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Marina Di Pilla ◽

Stefano Barco ◽

Clara Sacco ◽

Giovanni Barosi ◽

Corrado Lodigiani

Keyword(s):

Systematic Review ◽

Case Report ◽

Lower Limb ◽

Limb Ischemia ◽

Acute Limb Ischemia ◽

Review Of The Literature ◽

Heparin Induced Thrombocytopenia ◽

Lower Limb Ischemia ◽

Vein Thrombosis ◽

Left Lower Limb

Summary: A 49-year-old man was diagnosed with pre-fibrotic myelofibrosis after acute left lower-limb ischemia requiring amputation and portal vein thrombosis. After surgery he developed heparin-induced thrombocytopenia (HIT) with venous thromboembolism, successfully treated with argatroban followed by dabigatran. Our systematic review of the literature supports the use of dabigatran for suspected HIT.

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