scholarly journals Spectral prediction features as a solution for the search space size problem in proteogenomics

2021 ◽  
pp. 100076
Author(s):  
Steven Verbruggen ◽  
Siegfried Gessulat ◽  
Ralf Gabriels ◽  
Anna Matsaroki ◽  
Hendrik Van de Voorde ◽  
...  
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2009 ◽  
Vol 20 (07) ◽  
pp. 1063-1079
Author(s):  
ADIL AMIRJANOV

The formalism is presented for modeling of a genetic algorithm (GA) with an adjustment of a search space size. The formalism for modeling of GA with an adjustment of a search space size assumes that the environment and the population form a unique system. In this paper, the formalism is applied to a problem which exhibits an interesting dynamics reminiscent of stabilizing selection in population biology. The equations of motion was derived that expressed the macroscopic statistical properties of population after reproductive genetic operators and an adjustment of a search space size in terms of those prior to the operation. Predictions of the theory are compared with experiments and are shown to predict the average fitness and the variance fitness of the final population accurately.


2008 ◽  
Vol 19 (07) ◽  
pp. 1047-1062 ◽  
Author(s):  
ADIL AMIRJANOV

One way to improve a search strategy in a Genetic Algorithm (GA) is to reduce the search space towards the feasible region where the global optimum is located. The paper describes the effect of an adjustment of a search space size of GA on the macroscopic statistical properties of population such as the average fitness and the variance fitness of population. The set of equations of motion was derived for the one-max problem that expressed the macroscopic statistical properties of population after an adjustment of a search space size in terms of those prior to the operation.


2016 ◽  
Vol 645 ◽  
pp. 112-127 ◽  
Author(s):  
Reinhard Bauer ◽  
Tobias Columbus ◽  
Ignaz Rutter ◽  
Dorothea Wagner
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Author(s):  
Reinhard Bauer ◽  
Tobias Columbus ◽  
Ignaz Rutter ◽  
Dorothea Wagner
Keyword(s):  

2017 ◽  
Vol 25 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Rodrigo Morales ◽  
Francisco Chicano ◽  
Foutse Khomh ◽  
Giuliano Antoniol

1997 ◽  
Vol 6 ◽  
pp. 223-262 ◽  
Author(s):  
M. E. Pollack ◽  
D. Joslin ◽  
M. Paolucci

Several recent studies have compared the relative efficiency of alternative flaw selection strategies for partial-order causal link (POCL) planning. We review this literature, and present new experimental results that generalize the earlier work and explain some of the discrepancies in it. In particular, we describe the Least-Cost Flaw Repair (LCFR) strategy developed and analyzed by Joslin and Pollack (1994), and compare it with other strategies, including Gerevini and Schubert's (1996) ZLIFO strategy. LCFR and ZLIFO make very different, and apparently conflicting claims about the most effective way to reduce search-space size in POCL planning. We resolve this conflict, arguing that much of the benefit that Gerevini and Schubert ascribe to the LIFO component of their ZLIFO strategy is better attributed to other causes. We show that for many problems, a strategy that combines least-cost flaw selection with the delay of separable threats will be effective in reducing search-space size, and will do so without excessive computational overhead. Although such a strategy thus provides a good default, we also show that certain domain characteristics may reduce its effectiveness.


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