Introduction. Malignant melanoma accounts for 3% of all cancers in Europe.
Malignant melanoma of the genitourinary tract is very rare, accounting for
1% of all cases. In addition, primary malignant melanoma of the urethra
accounts for 0.2% of all melanomas and 4% of all urethral cancers. The
abnormal migration of melanocytes during the embryonic development may
explain their occurrence in the urethra. Also, vulva contains a relatively
high concentration of melanocytes, so it may be the reason for higher
incidence of malignant melanomas in females than in males, especially
located at the meatus or in the distal urethra. Case Report. A 60-year-old
woman presented with a solid tumor protruding through the vaginal introitus.
Computerized tomography revealed a 5 cm large tumor of the urethra,
infiltrating the bladder neck and the anterior vaginal wall. In addition, a
bilateral pelvic lymphadenopathy was observed. The patient underwent
anterior pelvic exenteration with urethrectomy, bilateral pelvic
lymphadenectomy and bilateral ureterocutaneostomy, followed by
immunochemotherapy. Nonetheless, the patient died 10 months after the
surgery. Conclusion. Urethral melanoma is a tumor with a very poor
prognosis and high recurrence rate (71%), even after wide surgical
resection, adjuvant radiotherapy, chemo and immunotherapy.
Primary anterior vaginal wall pure ammonium acid urate stone. Case report
