Nucleotide-binding oligomerization domain-2 (NOD2) regulates type-1 cytokine responses to Mycobacterium avium but is not required for host control of infection

2015 ◽  
Vol 17 (5) ◽  
pp. 337-344 ◽  
Author(s):  
Natália B. Carvalho ◽  
Fernanda S. Oliveira ◽  
Fábio A.V. Marinho ◽  
Leonardo A. de Almeida ◽  
Júlia S. Fahel ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Nucleotide Binding ◽  
Cytokine Responses ◽  
Type 1 Cytokine ◽  
Oligomerization Domain

scholarly journals Susceptibility to Polyomavirus-Induced Tumors in Inbred Mice: Role of Innate Immune Responses

2002 ◽  
Vol 76 (19) ◽  
pp. 9657-9663 ◽  
Author(s):  
Palanivel Velupillai ◽  
John P. Carroll ◽  
Thomas L. Benjamin
Keyword(s):  
Antigen Presenting Cells ◽  
Interleukin 10 ◽  
Cytokine Response ◽  
Innate Immune ◽  
Interleukin 12 ◽  
Cytokine Responses ◽  
Induced Tumors ◽  
Antigen Presenting ◽  
Type 1 Cytokine

ABSTRACT Mice of the PERA/Ei strain (PE mice) are highly susceptible to tumor induction by polyomavirus and transmit their susceptibility in a dominant manner in crosses with resistant C57BR/cdJ mice (BR mice). BR mice respond to polyomavirus infection with a type 1 cytokine response and develop effective cell-mediated immunity to the virus-induced tumors. By enumerating virus-specific CD8+ T cells and measuring cytokine responses, we show that the susceptibility of PE mice is due to the absence of a type 1 cytokine response and a concomitant failure to sustain virus-specific cytotoxic T lymphocytes. (PE × BR)F1 mice showed an initial type 1 response that became skewed toward type 2. Culture supernatants of splenocytes from infected PE mice stimulated in vitro contained high levels of interleukin-10 and no detectable gamma interferon, while those from BR mice showed the opposite pattern. Differences in the innate immune response to polyomavirus by antigen-presenting cells in PE mice and BR mice led to polarization of T-cell cytokine responses. Adherent cells from spleens of infected BR mice produced high levels of interleukin-12, while those from infected PE and F1 mice produced predominantly interleukin-10. PE and F1 mice infected by polyomavirus responded with increases in antigen-presenting cells expressing B7.2 costimulatory molecules, whereas BR mice responded with increased expression of B7.1. Administration of recombinant interleukin-12 along with virus resulted in partial protection of PE mice and provided complete protection against tumor development in F1 animals.

scholarly journals IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

Immunity ◽  
1996 ◽  
Vol 4 (5) ◽  
pp. 471-481 ◽  
Author(s):  
Jeanne Magram ◽  
Suzanne E Connaughton ◽  
Rajeev R Warrier ◽  
Daisy M Carvajal ◽  
Chang-you Wu ◽  
...  
Keyword(s):  
Cytokine Responses ◽  
Type 1 Cytokine ◽  
Deficient Mice

scholarly journals A Role for CD40-CD40 Ligand Interactions in the Generation of Type 1 Cytokine Responses in Human Leprosy

2000 ◽  
Vol 165 (3) ◽  
pp. 1506-1512 ◽  
Author(s):  
Paul S. Yamauchi ◽  
Joshua R. Bleharski ◽  
Koichi Uyemura ◽  
Jenny Kim ◽  
Peter A. Sieling ◽  
...  
Keyword(s):  
Cd40 Ligand ◽  
Cytokine Responses ◽  
Ligand Interactions ◽  
Type 1 Cytokine

Natural Antibodies Against Bone Morphogenic Proteins and Interferons in Healthy Donors and in Patients with Infections Linked to Type-1 Cytokine Responses

2011 ◽  
Vol 31 (9) ◽  
pp. 661-669 ◽  
Author(s):  
Melody Sauerborn ◽  
Esther van de Vosse ◽  
Diyar Delawi ◽  
Jaap T. van Dissel ◽  
Vera Brinks ◽  
...  
Keyword(s):  
Natural Antibodies ◽  
Bone Morphogenic Proteins ◽  
Cytokine Responses ◽  
Healthy Donors ◽  
Type 1 Cytokine

IL-12-Deficient Mice Are Defective but Not Devoid of Type 1 Cytokine Responses

1996 ◽  
Vol 795 (1 Interleukin 1) ◽  
pp. 60-70 ◽  
Author(s):  
JEANNE MAGRAM ◽  
JESSICA SFARRA ◽  
SUZANNE CONNAUGHTON ◽  
DENISE FAHERTY ◽  
RAJEEV WARRIER ◽  
...  
Keyword(s):  
Cytokine Responses ◽  
Type 1 Cytokine ◽  
Deficient Mice

scholarly journals Patent Filarial Infection Modulates Malaria-Specific Type 1 Cytokine Responses in an IL-10-Dependent Manner in a Filaria/Malaria-Coinfected Population

2009 ◽  
Vol 183 (2) ◽  
pp. 916-924 ◽  
Author(s):  
Simon Metenou ◽  
Benoit Dembélé ◽  
Siaka Konate ◽  
Housseini Dolo ◽  
Siaka Y. Coulibaly ◽  
...  
Keyword(s):  
Dependent Manner ◽  
Filarial Infection ◽  
Cytokine Responses ◽  
Type 1 Cytokine

scholarly journals Nucleotide‐binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions

FEBS Journal ◽  
2020 ◽  
Vol 287 (10) ◽  
pp. 2055-2069
Author(s):  
Min‐Young Kwon ◽  
Narae Hwang ◽  
Sung Hoon Back ◽  
Seon‐Jin Lee ◽  
Mark A. Perrella ◽  
...  
Keyword(s):  
Nucleotide Binding ◽  
Chop Expression ◽  
Atherosclerotic Lesions ◽  
Domain Protein ◽  
Oligomerization Domain
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