Survival of Mycobacterium tuberculosis and Mycobacterium bovis BCG in lysosomes in vivo

2017 ◽  
Vol 19 (11) ◽  
pp. 515-526 ◽  
Author(s):  
Varadharajan Sundaramurthy ◽  
Hannelie Korf ◽  
Ashima Singla ◽  
Nicole Scherr ◽  
Liem Nguyen ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
Mycobacterium Bovis Bcg

scholarly journals Protection Elicited by Two Glutamine Auxotrophs of Mycobacterium tuberculosis and In Vivo Growth Phenotypes of the Four Unique Glutamine Synthetase Mutants in a Murine Model

2006 ◽  
Vol 74 (11) ◽  
pp. 6491-6495 ◽  
Author(s):  
Sunhee Lee ◽  
Bo-Young Jeon ◽  
Svetoslav Bardarov ◽  
Mei Chen ◽  
Sheldon L. Morris ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Glutamine Synthetase ◽  
Mycobacterium Bovis ◽  
Murine Model ◽  
Triple Mutant ◽  
Auxotrophic Mutants ◽  
Bcg Vaccination ◽  
In Vivo Growth ◽  
Subcutaneous Immunization

ABSTRACT We generated four individual glutamine synthetase (GS) mutants (ΔglnA1, ΔglnA2, ΔglnA3, and ΔglnA4) and one triple mutant (ΔglnA1EA2) of Mycobacterium tuberculosis to investigate the roles of GS enzymes. Subcutaneous immunization with the ΔglnA1EA2 and ΔglnA1 glutamine auxotrophic mutants conferred protection on C57BL/6 mice against an aerosol challenge with virulent M. tuberculosis, which was comparable to that provided by Mycobacterium bovis BCG vaccination.

scholarly journals Multiple small RNAs identified in Mycobacterium bovis BCG are also expressed in Mycobacterium tuberculosis and Mycobacterium smegmatis

2010 ◽  
Vol 38 (12) ◽  
pp. 4067-4078 ◽  
Author(s):  
J. M. DiChiara ◽  
L. M. Contreras-Martinez ◽  
J. Livny ◽  
D. Smith ◽  
K. A. McDonough ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
Mycobacterium Smegmatis ◽  
Small Rnas ◽  
Mycobacterium Bovis Bcg

scholarly journals β-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages

2011 ◽  
Vol 51 (4) ◽  
pp. 233-242 ◽  
Author(s):  
Bret E. Betz ◽  
Abul K. Azad ◽  
Jessica D. Morris ◽  
Murugesan V.S. Rajaram ◽  
Larry S. Schlesinger
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
Intracellular Growth ◽  
Human Macrophages ◽  
Mycobacterium Bovis Bcg

In vivo efficiency of targeted norfloxacin against persistent, isoniazid-insensitive, Mycobacterium bovis BCG present in the physiologically hypoxic mouse liver

2005 ◽  
Vol 7 (7-8) ◽  
pp. 969-975 ◽  
Author(s):  
A.M. Balazuc ◽  
M. Lagranderie ◽  
P. Chavarot ◽  
P. Pescher ◽  
E. Roseeuw ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Mouse Liver ◽  
Mycobacterium Bovis Bcg

scholarly journals Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection

2009 ◽  
Vol 254 (2) ◽  
pp. 94-104 ◽  
Author(s):  
Nicole D. Pecora ◽  
Scott A. Fulton ◽  
Scott M. Reba ◽  
Michael G. Drage ◽  
Daimon P. Simmons ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mycobacterium Bovis ◽  
Murine Lung ◽  
Mycobacterium Bovis Bcg ◽  
Mhc Ii ◽  
Lung Macrophages ◽  
Aerosol Infection

Mycobacterium bovis BCG vaccination modulates TNF-α production after pulmonary challenge with virulent Mycobacterium tuberculosis in guinea pigs

Tuberculosis ◽  
2007 ◽  
Vol 87 (2) ◽  
pp. 155-165 ◽  
Author(s):  
Toshiko Yamamoto ◽  
Todd M. Lasco ◽  
Kazuyuki Uchida ◽  
Yoshitaka Goto ◽  
Amminikutty Jeevan ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
Guinea Pigs ◽  
Mycobacterium Bovis Bcg ◽  
Bcg Vaccination ◽  
Tnf Α
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