Heterogeneous copper-free Sonogashira coupling reaction of terminal alkynes with aryl halides over a quinoline-2-carboimine palladium complex immobilized on MCM-41

2008 ◽  
Vol 293 (1-2) ◽  
pp. 72-78 ◽  
Author(s):  
Kenichi Komura ◽  
Hideki Nakamura ◽  
Yoshihiro Sugi
Keyword(s):  
Palladium Complex ◽  
Coupling Reaction ◽  
Aryl Halides ◽  
Sonogashira Coupling ◽  
Terminal Alkynes ◽  
Sonogashira Coupling Reaction ◽  
Mcm 41

Microwave-assisted, Copper-free Sonogashira Coupling between Aryl Halides and Terminal Alkynes Using Recyclable Ionic Liquid and Catalyst.

2021 ◽  
Vol 18 ◽  
Author(s):  
Dau Xuan Duc ◽  
Nguyen Van Quoc
Keyword(s):  
Ionic Liquid ◽  
Coupling Reaction ◽  
Aryl Halides ◽  
Sonogashira Coupling ◽  
Terminal Alkynes ◽  
Considerable Decrease ◽  
Short Reaction Time ◽  
Microwave Assisted ◽  
Sonogashira Coupling Reaction ◽  
High Yields

: An efficient method for the Sonogashira coupling reaction between aryl halides and terminal alkynes has been developed. The reaction was performed in ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) under microwave irradiation. High yields of products were obtained in very short reaction time. Moreover, the medium and catalyst could be recovered and reused three times without considerable decrease in reaction yields.

scholarly journals The Utility of Sonogashira Coupling Reaction for the Derivatization of Aryl Halides with Fluorescent Alkyne

2018 ◽  
Vol 34 (10) ◽  
pp. 1183-1188 ◽  
Author(s):  
Naoyuki YASAKA ◽  
Naoya KISHIKAWA ◽  
Takumi HIGASHIJIMA ◽  
Kaname OHYAMA ◽  
Naotaka KURODA
Keyword(s):  
Coupling Reaction ◽  
Aryl Halides ◽  
Sonogashira Coupling ◽  
Sonogashira Coupling Reaction

Environmentally Benign Microwave-Assisted Sonogashira Preparation of Aromatic Compounds

2011 ◽  
Vol 695 ◽  
pp. 113-116 ◽  
Author(s):  
Suttikiat Puechmongkol ◽  
Boonchoat Paosawatyanyong ◽  
Worawan Bhanthumnavin
Keyword(s):  
Coupling Reaction ◽  
Environmentally Benign ◽  
Conventional Heating ◽  
Microwave Activation ◽  
Sonogashira Coupling ◽  
Terminal Alkynes ◽  
Mild Conditions ◽  
Aryl Bromides ◽  
Sonogashira Coupling Reaction ◽  
Type Coupling

An efficient Sonogashira-type coupling reaction of terminal alkynes and aryl bromides by microwave activation with short reaction time under mild conditions are presented. It is illustrated herein that the traditional Sonogashira coupling reaction can be achieved with a much more efficient yet environmentally friendly condition. In contrary to the usually required 10 mol% Pd loading and the use of conventional heating at 60 °C for 24 h in order for a reaction to proceed satisfactorily, with a 100 W microwave activation, the reaction of terminal alkynes with substituted aryl bromides can be achieved with only a 2.5 mol% Pd in 10 min. The yield was improved with microwave irradiation.

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