Comprehensive QSAR studies reveal structural insights into the NR2B subtype selective benzazepine derivatives as N-Methyl- -Aspartate receptor antagonists

Journal of Molecular Structure ◽

10.1016/j.molstruc.2019.07.068 ◽

2019 ◽

Vol 1197 ◽

pp. 617-627 ◽

Cited By ~ 2

Author(s):

Vishal P. Zambre ◽

Rajesh B. Patil ◽

Jaiprakash N. Sangshetti ◽

Sanjay D. Sawant

Keyword(s):

Receptor Antagonists ◽

Qsar Studies ◽

Aspartate Receptor ◽

Methyl Aspartate ◽

Subtype Selective ◽

Structural Insights

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Effects of Pan- and Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists on Cortical Spreading Depression in the Rat: Therapeutic Potential for Migraine

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.117101 ◽

2007 ◽

Vol 321 (2) ◽

pp. 564-572 ◽

Cited By ~ 64

Author(s):

Magali Peeters ◽

Martin J. Gunthorpe ◽

Paul J. L. M. Strijbos ◽

Paul Goldsmith ◽

Neil Upton ◽

...

Keyword(s):

Cortical Spreading Depression ◽

Spreading Depression ◽

Therapeutic Potential ◽

Receptor Antagonists ◽

Aspartate Receptor ◽

Subtype Selective

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Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-?-Aspartate receptor antagonists— I. Pharmacological characterization in Vitro

Neuropharmacology ◽

10.1016/s0028-3908(96)00049-4 ◽

1996 ◽

Vol 35 (6) ◽

pp. 643-654

Author(s):

S Urwyler

Keyword(s):

Heptanoic Acid ◽

Receptor Antagonists ◽

Pharmacological Characterization ◽

Aspartate Receptor ◽

Methyl Aspartate ◽

Derivatives Of

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Effects of Noncompetitive N-Methyl-?-Aspartate Receptor Antagonists on Opiate Tolerance and Physical Dependence

Neuropsychopharmacology ◽

10.1016/0893-133x(95)00088-u ◽

1995 ◽

Vol 13 (4) ◽

pp. 301-307 ◽

Cited By ~ 47

Author(s):

K Trujillo

Keyword(s):

Physical Dependence ◽

Receptor Antagonists ◽

Aspartate Receptor ◽

Methyl Aspartate ◽

Opiate Tolerance

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ChemInform Abstract: Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines.

ChemInform ◽

10.1002/chin.200101152 ◽

2001 ◽

Vol 32 (1) ◽

pp. no-no

Author(s):

Jon L. Wright ◽

et al. et al.

Keyword(s):

Biological Evaluation ◽

Receptor Antagonists ◽

Aspartate Receptor ◽

Subtype Selective ◽

Synthesis And Biological Evaluation

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Modulation of morphine analgesia by site-specific N-methyl--aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time

Pain ◽

10.1016/s0304-3959(04)00075-2 ◽

2004 ◽

Vol 109 (3) ◽

pp. 274-283

Author(s):

K NEMMANI

Keyword(s):

Morphine Analgesia ◽

Receptor Antagonists ◽

Site Specific ◽

Morphine Dose ◽

Aspartate Receptor ◽

Methyl Aspartate

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Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a Novel Class of Potent Competitive N-methyl-?-aspartate Receptor Antagonists. IIâPharmacological characterization in Vivo

Neuropharmacology ◽

10.1016/s0028-3908(96)00050-0 ◽

1996 ◽

Vol 35 (6) ◽

pp. 655-669

Author(s):

S Urwyler

Keyword(s):

Heptanoic Acid ◽

Receptor Antagonists ◽

Pharmacological Characterization ◽

Aspartate Receptor ◽

Methyl Aspartate ◽

Derivatives Of

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ChemInform Abstract: Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Benzimidazolone and Hydantoin as Phenol Replacements.

ChemInform ◽

10.1002/chin.200031147 ◽

2010 ◽

Vol 31 (31) ◽

pp. no-no

Author(s):

Robert M. Schelkun ◽

Po-wai Yuen ◽

Kevin Serpa ◽

Leonard T. Meltzer ◽

Lawrence D. Wise ◽

...

Keyword(s):

Receptor Antagonists ◽

Aspartate Receptor ◽

Subtype Selective

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Interactions Between N-Methyl-?-Aspartate Receptor Antagonists and the Discriminative Stimulus Effects of Morphine in Rats

Pharmacology Biochemistry and Behavior ◽

10.1016/s0091-3057(98)00006-9 ◽

1998 ◽

Vol 60 (2) ◽

pp. 507-517 ◽

Cited By ~ 10

Author(s):

A Bespalov

Keyword(s):

Discriminative Stimulus ◽

Receptor Antagonists ◽

Discriminative Stimulus Effects ◽

Aspartate Receptor ◽

Methyl Aspartate ◽

Stimulus Effects

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Modification of the glycine (co-activator) binding site of the N-methyl-?-aspartate receptor in the guinea pig fetus brain during development following hypoxia

Brain Research ◽

10.1016/s0006-8993(96)00528-8 ◽

1996 ◽

Vol 733 (1) ◽

pp. 15-20

Author(s):

B Razdan

Keyword(s):

Guinea Pig ◽

Binding Site ◽

Aspartate Receptor ◽

Methyl Aspartate ◽

Guinea Pig Fetus

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Quantitative Structure—Activity Relationship (QSAR) Studies on Sulfide Analogues as Potent M2 Muscarinic Receptor Antagonists.

ChemInform ◽

10.1002/chin.200622145 ◽

2006 ◽

Vol 37 (22) ◽

Author(s):

A. K. Srivastava ◽

A. A. Khan ◽

Abha Tripathi ◽

Archana Archana

Keyword(s):

Muscarinic Receptor ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Receptor Antagonists ◽

Qsar Studies ◽

Structure Activity ◽

Muscarinic Receptor Antagonists ◽

M2 Muscarinic Receptor

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Comprehensive QSAR studies reveal structural insights into the NR2B subtype selective benzazepine derivatives as N-Methyl- -Aspartate receptor antagonists

Effects of Pan- and Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists on Cortical Spreading Depression in the Rat: Therapeutic Potential for Migraine

Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-?-Aspartate receptor antagonists— I. Pharmacological characterization in Vitro

Effects of Noncompetitive N-Methyl-?-Aspartate Receptor Antagonists on Opiate Tolerance and Physical Dependence

ChemInform Abstract: Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines.

Modulation of morphine analgesia by site-specific N-methyl--aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time

Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a Novel Class of Potent Competitive N-methyl-?-aspartate Receptor Antagonists. IIâPharmacological characterization in Vivo

ChemInform Abstract: Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Benzimidazolone and Hydantoin as Phenol Replacements.

Interactions Between N-Methyl-?-Aspartate Receptor Antagonists and the Discriminative Stimulus Effects of Morphine in Rats

Modification of the glycine (co-activator) binding site of the N-methyl-?-aspartate receptor in the guinea pig fetus brain during development following hypoxia

Quantitative Structure—Activity Relationship (QSAR) Studies on Sulfide Analogues as Potent M2 Muscarinic Receptor Antagonists.

Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a Novel Class of Potent Competitive N-methyl-?-aspartate Receptor Antagonists. IIâPharmacological characterization in Vivo