A preformulation co-crystal screening case study: Polymorphic co-crystals of an imidazopyridazine antimalarial drug lead with the coformer succinic acid

2020 ◽  
Vol 1204 ◽  
pp. 127561 ◽  
Author(s):  
Terence J. Noonan ◽  
Kelly Chibale ◽  
Susan A. Bourne ◽  
Mino R. Caira
Keyword(s):  
Succinic Acid ◽  
Antimalarial Drug ◽  
Drug Lead

scholarly journals An Overview of Computational Approaches in Structure Based Drug Design

1970 ◽  
Vol 2 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Dipali Singh ◽  
Anushree Tripathi ◽  
Gautam Kumar
Keyword(s):  
Drug Design ◽  
Computer Aided Drug Design ◽  
Structure Based Drug Design ◽  
Computational Approaches ◽  
Ras Protein ◽  
Design Structure ◽  
Drug Lead ◽  
Computer Aided ◽  
Drug Designing

Drug design is a costly and difficult process. Drug must fulfill several criteria of being active, nontoxic and bioavailable. The conventional way of synthesizing drugs is a monotonous process. But computer aided drug design is a proficient way to overcome the tedious process of conventional method. Drugs can be designed computationally by structure or target based drug designing (SBDD). This review summarizes the methods of structure based drug design, usage of related softwares and a case study that explores to find a suitable drug (lead) molecule for the mutated state of H-Ras protein in order to prevent complex formation with Raf protein.Keywords: computer aided drug design; structure based drug design; Ras-proteinDOI: http://dx.doi.org/10.3126/njb.v2i1.5680Nepal Journal of Biotechnology Jan.2012, Vol.2(1): 53-61

Cocrystal and Salt Forms of an Imidazopyridazine Antimalarial Drug Lead

2019 ◽  
Vol 108 (7) ◽  
pp. 2349-2357 ◽  
Author(s):  
Terence J. Noonan ◽  
Kelly Chibale ◽  
Peter M. Cheuka ◽  
Susan A. Bourne ◽  
Mino R. Caira
Keyword(s):  
Antimalarial Drug ◽  
Drug Lead ◽  
Salt Forms

scholarly journals Platform molecule from sustainable raw materials; case study succinic acid

2021 ◽  
Author(s):  
Alaa Salma ◽  
Hayet Djelal ◽  
Rawa Abdallah ◽  
Florence Fourcade ◽  
Abdeltif Amrane
Keyword(s):  
Succinic Acid ◽  
Raw Materials

scholarly journals Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines

2021 ◽  
Vol 33 ◽  
pp. 116018
Author(s):  
Yuki Mizukawa ◽  
Mayumi Ikegami-Kawai ◽  
Masako Horiuchi ◽  
Marcel Kaiser ◽  
Masayoshi Kojima ◽  
...  
Keyword(s):  
Antimalarial Drug ◽  
Drug Lead

Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study

2018 ◽  
Vol 18 (12) ◽  
pp. 7401-7409 ◽  
Author(s):  
Andrey G. Ogienko ◽  
Svetlana A. Myz ◽  
Anna A. Ogienko ◽  
Andrey A. Nefedov ◽  
Andrey S. Stoporev ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Solid Dispersions ◽  
Pharmaceutical Compounds ◽  
Water Soluble ◽  
Acid System ◽  
Poorly Water Soluble

Five Solid Forms of a Potent Imidazopyridazine Antimalarial Drug Lead: A Preformulation Study

2019 ◽  
Vol 19 (8) ◽  
pp. 4683-4697 ◽  
Author(s):  
Terence J. Noonan ◽  
Kelly Chibale ◽  
Peter M. Cheuka ◽  
Malkeet Kumar ◽  
Susan A. Bourne ◽  
...  
Keyword(s):  
Antimalarial Drug ◽  
Drug Lead ◽  
Preformulation Study
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