One-pot synthesis of some new regioseletive 4β-pyrazolepodophyllotoxins as DNA topoisomerase-II targeting anticancer agents

2021 ◽  
pp. 131724
Author(s):  
Rajkumar Nagavath ◽  
Satheesh Kumar Nukala ◽  
Narsimha Sirassu ◽  
Ravikumar Reddy Sagam ◽  
Ravinder Manchal ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
One Pot ◽  
Dna Topoisomerase ◽  
One Pot Synthesis

ChemInform Abstract: An Efficient One-Pot Synthesis of Benzothiazolo-4β-anilino-podophyllotoxin Congeners: DNA Topoisomerase-II Inhibition and Anticancer Activity.

ChemInform ◽  
2011 ◽  
Vol 42 (20) ◽  
pp. no-no
Author(s):  
Ahmed Kamal ◽  
B. Ashwini Kumar ◽  
Paidakula Suresh ◽  
Nagula Shankaraiah ◽  
M. Shiva Kumar
Keyword(s):  
Anticancer Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
One Pot ◽  
Dna Topoisomerase ◽  
One Pot Synthesis

Synthesis and biological evaluation of 4β-benzoxazolepodophyllotoxin hybrids as DNA topoisomerase-II targeting anticancer agents

RSC Advances ◽  
2015 ◽  
Vol 5 (118) ◽  
pp. 97314-97319 ◽  
Author(s):  
Suresh Paidakula ◽  
Shravankumar Kankala ◽  
Ranjith kumar Kankala ◽  
Bhasker Juluru ◽  
Sreekantha B. Jonnalagadda ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Dna Topoisomerase Ii ◽  
Human Tumour ◽  
Dna Topoisomerase ◽  
Tumour Cell Lines ◽  
Hoechst Staining ◽  
Synthesis And Biological Evaluation ◽  
Human Tumour Cell Lines

A series of new 4β-benzoxazolepodophyllotoxin compounds (9a–j) were prepared and screened for molecular modelling and cytotoxicity against various human tumour cell lines. Cell apoptosis evaluation was performed using Hoechst staining.

Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors

2018 ◽  
Vol 144 ◽  
pp. 557-571 ◽  
Author(s):  
Manda Sathish ◽  
Botla Kavitha ◽  
V. Lakshma Nayak ◽  
Yellaiah Tangella ◽  
Ayyappan Ajitha ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Topoisomerase Ii Inhibitors
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