scholarly journals A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders

Neuron ◽  
2019 ◽  
Vol 101 (6) ◽  
pp. 1070-1088 ◽  
Author(s):  
Claudia Bagni ◽  
R. Suzanne Zukin
Keyword(s):  
Autism Spectrum Disorders ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Spectrum Disorders

Parental reports on early language and motor milestones in fragile X syndrome with and without autism spectrum disorders

2012 ◽  
Vol 16 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Rebecca Hinton ◽  
Dejan B. Budimirovic ◽  
Peter B. Marschik ◽  
Victor B. Talisa ◽  
Christa Einspieler ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Early Language ◽  
Parental Reports ◽  
Spectrum Disorders

scholarly journals A comparison of family financial and employment impacts of fragile X syndrome, autism spectrum disorders, and intellectual disability

2014 ◽  
Vol 35 (7) ◽  
pp. 1518-1527 ◽  
Author(s):  
Lijing Ouyang ◽  
Scott D. Grosse ◽  
Catharine Riley ◽  
Julie Bolen ◽  
Ellen Bishop ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Intellectual Disability ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Spectrum Disorders ◽  
Employment Impacts

scholarly journals Abnormal Mechanisms of Plasticity and Metaplasticity in Autism Spectrum Disorders and Fragile X Syndrome

2016 ◽  
Vol 26 (7) ◽  
pp. 617-624 ◽  
Author(s):  
Lindsay M. Oberman ◽  
Fritz Ifert-Miller ◽  
Umer Najib ◽  
Shahid Bashir ◽  
Joseph Gonzalez-Heydrich ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Spectrum Disorders ◽  
Mechanisms Of Plasticity

scholarly journals Do Fragile X Syndrome and Other Intellectual Disorders Converge at Aberrant Pre-mRNA Splicing?

2021 ◽  
Vol 12 ◽  
Author(s):  
Sneha Shah ◽  
Joel D. Richter
Keyword(s):  
Autism Spectrum Disorders ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Protein Product ◽  
Aberrant Splicing ◽  
Brain Transcriptome ◽  
Post Mortem Brain ◽  
Spectrum Disorders ◽  
General Translation

Fragile X Syndrome is a neuro-developmental disorder caused by the silencing of the FMR1 gene, resulting in the loss of its protein product, FMRP. FMRP binds mRNA and represses general translation in the brain. Transcriptome analysis of the Fmr1-deficient mouse hippocampus reveals widespread dysregulation of alternative splicing of pre-mRNAs. Many of these aberrant splicing changes coincide with those found in post-mortem brain tissue from individuals with autism spectrum disorders (ASDs) as well as in mouse models of intellectual disability such as PTEN hamartoma syndrome (PHTS) and Rett Syndrome (RTT). These splicing changes could result from chromatin modifications (e.g., in FXS, RTT) and/or splicing factor alterations (e.g., PTEN, autism). Based on the identities of the RNAs that are mis-spliced in these disorders, it may be that they are at least partly responsible for some shared pathophysiological conditions. The convergence of splicing aberrations among these autism spectrum disorders might be crucial to understanding their underlying cognitive impairments.

scholarly journals Daily Work Stress and Awakening Cortisol in Mothers of Individuals with Autism Spectrum Disorders or Fragile X Syndrome

2014 ◽  
Vol 63 (1) ◽  
pp. 135-147 ◽  
Author(s):  
Jen D. Wong ◽  
Marsha R. Mailick ◽  
Jan S. Greenberg ◽  
Jinkuk Hong ◽  
Christopher L. Coe
Keyword(s):  
Autism Spectrum Disorders ◽  
Fragile X Syndrome ◽  
Work Stress ◽  
Fragile X ◽  
Autism Spectrum ◽  
Daily Work ◽  
Spectrum Disorders

scholarly journals Aripiprazole in autism spectrum disorders and fragile X syndrome

2010 ◽  
Vol 7 (3) ◽  
pp. 258-263 ◽  
Author(s):  
Craig A. Erickson ◽  
Kimberly A. Stigler ◽  
David J. Posey ◽  
Christopher J. McDougle
Keyword(s):  
Autism Spectrum Disorders ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Spectrum Disorders

The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome

2011 ◽  
Vol 81 (9) ◽  
pp. 1078-1086 ◽  
Author(s):  
David R. Hampson ◽  
Daniel C. Adusei ◽  
Laura K.K. Pacey
Keyword(s):  
Autism Spectrum Disorders ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
Autism Spectrum ◽  
Spectrum Disorders
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