Activation of adenosine A2A receptors in the olfactory tubercle promotes sleep in rodents

2020 ◽  
Vol 168 ◽  
pp. 107923 ◽  
Author(s):  
Rui Li ◽  
Yi-Qun Wang ◽  
Wen-Ying Liu ◽  
Meng-Qi Zhang ◽  
Lei Li ◽  
...  
Keyword(s):  
Olfactory Tubercle ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a

Activation of adenosine A2A receptors in the olfactory tubercle promotes sleep in rodents

2019 ◽  
Vol 64 ◽  
pp. S412
Author(s):  
Y.-Q. Wang ◽  
R. Li ◽  
W.-Y. Liu ◽  
M.-Q. Zhang ◽  
L. Li ◽  
...  
Keyword(s):  
Olfactory Tubercle ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a

Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC

2004 ◽  
Vol 20 (8) ◽  
pp. 2203-2213 ◽  
Author(s):  
Guadalupe Soria ◽  
Anna Castane ◽  
Fernando Berrendero ◽  
Catherine Ledent ◽  
Marc Parmentier ◽  
...  
Keyword(s):  
Physical Dependence ◽  
Place Conditioning ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a

scholarly journals A Crucial Role for Forebrain Adenosine A2A Receptors in Amphetamine Sensitization

2004 ◽  
Vol 30 (5) ◽  
pp. 891-900 ◽  
Author(s):  
Elena Bastia ◽  
Yue-Hang Xu ◽  
Angela C Scibelli ◽  
Yuan-Ji Day ◽  
Joel Linden ◽  
...  
Keyword(s):  
Crucial Role ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a ◽  
Amphetamine Sensitization

THE ROLE OF ADENOSINE A2A RECEPTORS IN THE NEUROLEPTIC-INDUCED c-Fos EXPRESSION

1998 ◽  
Vol 9 (Supplement) ◽  
pp. S93
Author(s):  
J. Wardasa ◽  
A. Pinna ◽  
A. Cozzolino ◽  
M. Morellib
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Fos Expression ◽  
Adenosine A2a

Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A2A receptors

Life Sciences ◽  
2006 ◽  
Vol 79 (3) ◽  
pp. 252-258 ◽  
Author(s):  
Mei-Kuang Lu ◽  
Jing-Jy Cheng ◽  
Wen-Lin Lai ◽  
Yen-Ru Lin ◽  
Nai-Kuei Huang
Keyword(s):  
Pc12 Cells ◽  
Active Component ◽  
Serum Deprivation ◽  
Adenosine A2a Receptors ◽  
Antrodia Cinnamomea ◽  
A2a Receptors ◽  
Induced Apoptosis ◽  
Adenosine A2a

Afferent arteriolar adenosine A2a receptors are coupled to KATP in in vitro perfused hydronephrotic rat kidney

1999 ◽  
Vol 277 (6) ◽  
pp. F926-F933 ◽  
Author(s):  
Lilong Tang ◽  
Michael Parker ◽  
Qing Fei ◽  
Rodger Loutzenhiser
Keyword(s):  
Rat Kidney ◽  
Afferent Arteriole ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
High Affinity ◽  
Vasodilatory Response ◽  
Renal Microvasculature ◽  
Adenosine A2a ◽  
Arteriolar Vasodilation

Adenosine is known to exert dual actions on the afferent arteriole, eliciting vasoconstriction, by activating A1 receptors, and vasodilation at higher concentrations, by activating lower-affinity A2 receptors. We could demonstrate both of these known adenosine responses in the in vitro perfused hydronephrotic rat kidney. Thus, 1.0 μM adenosine elicited a transient vasoconstriction blocked by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), and 10–30 μM adenosine reversed KCl-induced vasoconstriction. However, when we examined the effects of adenosine on pressure-induced afferent arteriolar vasoconstriction, we observed a third action. In this setting, a high-affinity adenosine vasodilatory response was observed at concentrations of 10–300 nM. This response was blocked by both 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl-amino]ethyl)phenol (ZM-241385) and glibenclamide and was mimicked by 2-phenylaminoadenosine (CV-1808) (IC50 of 100 nM), implicating adenosine A2a receptors coupled to ATP-sensitive K channels (KATP). Like adenosine, 5′- N-ethylcarboxamidoadenosine (NECA) elicited both glibenclamide-sensitive and glibenclamide-insensitive vasodilatory responses. The order of potency for the glibenclamide-sensitive component was NECA > adenosine = CV-1808. Our findings suggest that, in addition to the previously described adenosine A1 and low-affinity A2b receptors, the renal microvasculature is also capable of expressing high-affinity adenosine A2areceptors. This renal adenosine receptor elicits afferent arteriolar vasodilation at submicromolar adenosine levels by activating KATP.

scholarly journals Forebrain Adenosine A2A Receptors Contribute to L-3,4-Dihydroxyphenylalanine-Induced Dyskinesia in Hemiparkinsonian Mice

2006 ◽  
Vol 26 (52) ◽  
pp. 13548-13555 ◽  
Author(s):  
D. Xiao ◽  
E. Bastia ◽  
Y.-H. Xu ◽  
C. L. Benn ◽  
J.-H. J. Cha ◽  
...  
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a

scholarly journals Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-d-aspartate effects

2005 ◽  
Vol 95 (4) ◽  
pp. 1188-1200 ◽  
Author(s):  
M. T. Tebano ◽  
A. Martire ◽  
N. Rebola ◽  
R. Pepponi ◽  
M. R. Domenici ◽  
...  
Keyword(s):  
Adenosine A2a Receptors ◽  
Metabotropic Glutamate ◽  
A2a Receptors ◽  
Adenosine A2a
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