Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia

2021 ◽  
Vol 186 ◽  
pp. 108454
Author(s):  
Jessica Hayes ◽  
Bettina Laursen ◽  
Elin Eneberg ◽  
Jan Kehler ◽  
Lars Kyhn Rasmussen ◽  
...  
Keyword(s):  
Cortical Activity ◽  
Prefrontal Cortical ◽  
Phosphodiesterase Type ◽  
Medial Prefrontal Cortical

scholarly journals The Neural Sociometer: Brain Mechanisms Underlying State Self-esteem

2011 ◽  
Vol 23 (11) ◽  
pp. 3448-3455 ◽  
Author(s):  
Naomi I. Eisenberger ◽  
Tristen K. Inagaki ◽  
Keely A. Muscatell ◽  
Kate E. Byrne Haltom ◽  
Mark R. Leary
Keyword(s):  
Negative Feedback ◽  
Cortical Activity ◽  
Self Esteem ◽  
Anterior Insula ◽  
Lower State ◽  
Social Connection ◽  
Prefrontal Cortical ◽  
Referential Processing ◽  
Neural Underpinnings ◽  
Medial Prefrontal Cortical

On the basis of the importance of social connection for survival, humans may have evolved a “sociometer”—a mechanism that translates perceptions of rejection or acceptance into state self-esteem. Here, we explored the neural underpinnings of the sociometer by examining whether neural regions responsive to rejection or acceptance were associated with state self-esteem. Participants underwent fMRI while viewing feedback words (“interesting,” “boring“) ostensibly chosen by another individual (confederate) to describe the participant's previously recorded interview. Participants rated their state self-esteem in response to each feedback word. Results demonstrated that greater activity in rejection-related neural regions (dorsal ACC, anterior insula) and mentalizing regions was associated with lower-state self-esteem. Additionally, participants whose self-esteem decreased from prescan to postscan versus those whose self-esteem did not showed greater medial prefrontal cortical activity, previously associated with self-referential processing, in response to negative feedback. Together, the results inform our understanding of the origin and nature of our feelings about ourselves.

Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: Implications for mood disorders

2014 ◽  
Vol 223 (3) ◽  
pp. 253-260 ◽  
Author(s):  
Ana D. Stan ◽  
Claudiu V. Schirda ◽  
Michele A. Bertocci ◽  
Genna M. Bebko ◽  
Dina M. Kronhaus ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Cortical Activity ◽  
Prefrontal Cortical ◽  
Medial Prefrontal Cortical
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