The influence of NMDA receptors in the dorsomedial striatum on response reversal learning

2004 ◽  
Vol 82 (2) ◽  
pp. 81-89 ◽  
Author(s):  
C PALENCIA
Keyword(s):  
Nmda Receptors ◽  
Reversal Learning ◽  
Response Reversal ◽  
Dorsomedial Striatum

scholarly journals Impaired probabilistic reversal learning in youths with mood and anxiety disorders

2009 ◽  
Vol 40 (7) ◽  
pp. 1089-1100 ◽  
Author(s):  
D. P. Dickstein ◽  
E. C. Finger ◽  
M. A. Brotman ◽  
B. A. Rich ◽  
D. S. Pine ◽  
...  
Keyword(s):  
Reversal Learning ◽  
Neuropsychological Test ◽  
Affective Neuroscience ◽  
Typically Developing ◽  
Primary Analysis ◽  
Behavioral Deficits ◽  
Learning Impairments ◽  
Response Reversal ◽  
Severe Mood Dysregulation ◽  
Probabilistic Reversal Learning

BackgroundFrom an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment associations through trial and error and then reverse them. We sought to determine the specificity of previously demonstrated reversal learning impairments in youths with bipolar disorder (BD) by now comparing BD youths to those with severe mood dysregulation (SMD), major depressive disorder (MDD), anxiety (ANX), and healthy controls.MethodWe administered the probabilistic response reversal (PRR) task to 165 pediatric participants aged 7–17 years with BD (n=35), SMD (n=35), ANX (n=42), MDD (n=18) and normal controls (NC; n=35). Our primary analysis compared PRR performance across all five groups matched for age, sex and IQ.ResultsCompared to typically developing controls, probabilistic reversal learning was impaired in BD youths, with a trend in those with MDD (p=0.07).ConclusionsOur results suggest that reversal learning deficits are present in youths with BD and possibly those with MDD. Further work is necessary to elucidate the specificity of neural mechanisms underlying such behavioral deficits.

scholarly journals Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum

Channels ◽  
2011 ◽  
Vol 5 (3) ◽  
pp. 205-209 ◽  
Author(s):  
Jun Wang ◽  
Maria Fe Lanfranco ◽  
Stuart L. Gibb ◽  
Dorit Ron
Keyword(s):  
Nmda Receptors ◽  
Dorsomedial Striatum

The contribution of spatial cues to memory: Direction, but not cue, changes support response reversal learning.

2009 ◽  
Vol 35 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Sandra L. Wright ◽  
Dene Williams ◽  
John H. Evans ◽  
Darlene M. Skinner ◽  
Gerard M. Martin
Keyword(s):  
Reversal Learning ◽  
Spatial Cues ◽  
Response Reversal

scholarly journals Distance and direction, but not light cues, support response reversal learning

2018 ◽  
Vol 47 (1) ◽  
pp. 38-46
Author(s):  
S. L. Wright ◽  
G. M. Martin ◽  
C. M. Thorpe ◽  
K. Haley ◽  
D. M. Skinner
Keyword(s):  
Reversal Learning ◽  
Response Reversal

scholarly journals Long-Lasting Adaptations of the NR2B-Containing NMDA Receptors in the Dorsomedial Striatum Play a Crucial Role in Alcohol Consumption and Relapse

2010 ◽  
Vol 30 (30) ◽  
pp. 10187-10198 ◽  
Author(s):  
J. Wang ◽  
M. F. Lanfranco ◽  
S. L. Gibb ◽  
Q. V. Yowell ◽  
S. Carnicella ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Nmda Receptors ◽  
Crucial Role ◽  
Dorsomedial Striatum
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