Parkinsonism with Akinetic Mutism following Osmotic Demyelination Syndrome in a SARS-CoV-2 infected Elderly Diabetic Woman: A Case Report

We report a case of a middle aged lady who presented with alteration of consciousness and dysphasia. She was found to have hyponatremia which was corrected rapidly. After initial improvement, she subsequently developed marked deterioration of conscious level with upper motor sign signs in all four limbs. Osmotic demyelination syndrome was diagnosed by MRI. Severe hyponatremia carries a risk of cerebral edema with a significant mortality, but correcting it too rapidly can result in even more disastrous condition- osmotic demyelination syndrome. doi: 10.3329/taj.v21i2.3800 TAJ 2008; 21(2): 170-173

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Secondary parkinsonism due to osmotic demyelination syndrome: a case report

The Egyptian Journal of Internal Medicine ◽

10.4103/1110-7782.174950 ◽

2015 ◽

Vol 27 (4) ◽

pp. 157 ◽

Cited By ~ 1

Author(s):

WaseemR Dar ◽

NajeebU Sofi ◽

Muzamil Latief ◽

ImtiyazA Dar ◽

Moomin Hussain

Keyword(s):

Case Report ◽

Osmotic Demyelination Syndrome ◽

Osmotic Demyelination

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Osmotic Demyelination Syndrome: Why Should Hypernatremia be Corrected Slowly? A Case Report

British Journal of Medicine and Medical Research ◽

10.9734/bjmmr/2014/8262 ◽

2014 ◽

Vol 4 (18) ◽

pp. 3512-3518

Author(s):

C. Rajasekharan

Keyword(s):

Case Report ◽

Osmotic Demyelination Syndrome ◽

Osmotic Demyelination

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Osmotic demyelination syndrome improving after immune-modulating treatment: Case report and literature review

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2021.106811 ◽

2021 ◽

pp. 106811

Author(s):

Stefania Kalampokini ◽

Artemios Artemiadis ◽

Panagiotis Zis ◽

Linos Hadjihannas ◽

Giorgos Parpas ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Osmotic Demyelination Syndrome ◽

Osmotic Demyelination

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Excessive Sodium Bicarbonate Infusion May Result in Osmotic Demyelination Syndrome During Treatment of Diabetic Ketoacidosis: A Case Report

Diabetes Therapy ◽

10.1007/s13300-019-0592-8 ◽

2019 ◽

Vol 10 (2) ◽

pp. 765-771 ◽

Cited By ~ 1

Author(s):

Hui-Chi Hsieh ◽

Shin-Hwar Wu ◽

Chun-Ching Chiu ◽

Keng-Chu Ko

Keyword(s):

Case Report ◽

Sodium Bicarbonate ◽

Diabetic Ketoacidosis ◽

Osmotic Demyelination Syndrome ◽

Osmotic Demyelination ◽

Bicarbonate Infusion ◽

Sodium Bicarbonate Infusion

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Osmotic Demyelination Syndrome with Recent Chemotherapy in Normonatremic Patient: A Case Report

Journal of the Korean Society of Radiology ◽

10.3348/jksr.2014.71.5.201 ◽

2014 ◽

Vol 71 (5) ◽

pp. 201

Author(s):

Sungjae Lee ◽

Hye Jin Baek ◽

Hyun Kyung Jung ◽

Seon-Jeong Kim ◽

Yedaun Lee ◽

...

Keyword(s):

Case Report ◽

Osmotic Demyelination Syndrome ◽

Osmotic Demyelination

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Case Report: Osmotic Demyelination Syndrome in an Adolescent with Neuromyelitis Optica

International Journal of MS Care ◽

10.7224/1537-2073.2016-077 ◽

2018 ◽

Vol 20 (3) ◽

pp. 142-144 ◽

Cited By ~ 1

Author(s):

Sarah Kariv ◽

Kathleen Bateman

Keyword(s):

Magnetic Resonance Imaging ◽

Case Report ◽

Magnetic Resonance ◽

Neuromyelitis Optica ◽

Area Postrema ◽

Imaging Features ◽

Osmotic Demyelination Syndrome ◽

Resonance Imaging ◽

Osmotic Demyelination ◽

Spectrum Disorders

A 17-year-old girl presented with intractable vomiting due to area postrema involvement in the first presentation of seronegative neuromyelitis optica (NMO). During the course of her illness, she developed mild hyponatremia, and magnetic resonance imaging revealed abnormalities consistent with the co-occurrence of osmotic demyelination syndrome (ODS). This combination of imaging features is novel, and this case expands the spectrum of brain abnormalities seen in NMO and NMO spectrum disorders. It was suspected that NMO may predispose to ODS by causing astrocyte dysfunction involving aquaporin 4 water channels, which are implicated in both conditions.

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