Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord

Pain ◽  
2005 ◽  
Vol 115 (1) ◽  
pp. 171-181 ◽  
Author(s):  
Achim Schmidtko ◽  
Domenico Del Turco ◽  
Ovidiu Coste ◽  
Corina Ehnert ◽  
Ellen Niederberger ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Synaptic Vesicle ◽  
Essential Role ◽  
Glutamate Release ◽  
Synaptic Vesicle Protein ◽  
Synapsin Ii ◽  
Vesicle Protein

scholarly journals Synaptic Vesicle Protein 2 (SV2) does not hydrolyze ATP

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 209
Author(s):  
Jia Yao ◽  
Sandra M. Bajjalieh
Keyword(s):  
Atpase Activity ◽  
Synaptic Vesicle ◽  
Neurotransmitter Release ◽  
Endocrine Cells ◽  
Essential Role ◽  
Adenine Nucleotides ◽  
Regulated Secretion ◽  
Synaptic Vesicle Protein ◽  
Vesicle Protein

Synaptic vesicle protein 2 (SV2) is a transporter-like protein specifically expressed in endocrine cells and neurons, where it is localized to vesicles that undergo regulated secretion and plays an essential role in regulating neurotransmitter release. SV2 binds adenine nucleotides including ATP. Analysis of ATP transport revealed that SV2 is not an ATP transporter, nor does it affect ATP transport. As a further step toward understanding how ATP binding contributes to SV2 function, we investigated whether SV2 is an ATPase using an in vitro measure of ATPase activity. The study reported here indicates that SV2 does not have ATPase activity. Thus, binding to adenine nucleotides likely modulates other actions of SV2.

Characterization of [3H]ucb 30889 binding to synaptic vesicle protein 2A in the rat spinal cord

2005 ◽  
Vol 520 (1-3) ◽  
pp. 70-76 ◽  
Author(s):  
Nathalie Lambeng ◽  
Michel Gillard ◽  
Pascale Vertongen ◽  
Bruno Fuks ◽  
Pierre Chatelain
Keyword(s):  
Spinal Cord ◽  
Synaptic Vesicle ◽  
Rat Spinal Cord ◽  
Synaptic Vesicle Protein ◽  
Vesicle Protein ◽  
Synaptic Vesicle Protein 2A

Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons

Science ◽  
1994 ◽  
Vol 264 (5161) ◽  
pp. 977-979 ◽  
Author(s):  
A Ferreira ◽  
K. Kosik ◽  
P Greengard ◽  
H. Han
Keyword(s):  
Synaptic Vesicle ◽  
Protein Deficiency ◽  
Synaptic Vesicle Protein ◽  
Synapsin Ii ◽  
Vesicle Protein

scholarly journals Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

2011 ◽  
Vol 7 (3) ◽  
pp. e1002008 ◽  
Author(s):  
Lisheng Peng ◽  
William H. Tepp ◽  
Eric A. Johnson ◽  
Min Dong
Keyword(s):  
Synaptic Vesicle ◽  
Botulinum Neurotoxin ◽  
Synaptic Vesicle Protein ◽  
Vesicle Protein

scholarly journals Synaptic Vesicle Protein 2 (SV2) Isoforms

2012 ◽  
Vol 13 (10) ◽  
pp. 5063-5067 ◽  
Author(s):  
Cindy Bandala ◽  
A. Miliar-Garcia ◽  
C.M. Mejia-Barradas ◽  
M. Anaya-Ruiz ◽  
J.P. Luna-Arias ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Synaptic Vesicle Protein ◽  
Vesicle Protein
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