rat cortex
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2021 ◽  
Author(s):  
Jing-Ying Lin ◽  
Tsung-Jung Ho ◽  
Bruce Chi-Kang Tsai ◽  
Chien-Yi Chiang ◽  
Hui-Chuan Kao ◽  
...  

2021 ◽  
Author(s):  
Sergiy Chornyy ◽  
Aniruddha Das ◽  
Julie Borovicka ◽  
Davina Patel ◽  
Hugh Chan ◽  
...  

2021 ◽  
Vol 14 ◽  
Author(s):  
Yeya Yu ◽  
Xiaoyu Wei ◽  
Qiuting Deng ◽  
Qing Lan ◽  
Yiping Guo ◽  
...  

Rats have been widely used as an experimental organism in psychological, pharmacological, and behavioral studies by modeling human diseases such as neurological disorders. It is critical to identify and characterize cell fate determinants and their regulatory mechanisms in single-cell resolutions across rat brain regions. Here, we applied droplet-based single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) to systematically profile the single-cell chromatin accessibility across four dissected brain areas in adult Sprague–Dawley (SD) rats with a total of 59,023 single nuclei and identified 16 distinct cell types. Interestingly, we found that different cortex regions exhibit diversity in both cellular compositions and gene regulatory regions. Several cell-type-specific transcription factors (TFs), including SPI1, KLF4, KLF6, and NEUROD2, have been shown to play important roles during the pathogenesis of various neurological diseases, such as Alzheimer’s disease (AD), astrocytic gliomas, autism spectrum disorder (ASD), and intellectual disabilities. Therefore, our single-nucleus atlas of rat cortex could serve as an invaluable resource for dissecting the regulatory mechanisms underlying diverse cortex cell fates and further revealing the regulatory networks of neuropathogenesis.


2021 ◽  
Vol 8 (02) ◽  
Author(s):  
Robert H. Wilson ◽  
Christian Crouzet ◽  
Mohammad Torabzadeh ◽  
Afsheen Bazrafkan ◽  
Niki Maki ◽  
...  

2020 ◽  
Vol 1749 ◽  
pp. 147126
Author(s):  
Alexandria Béland-Millar ◽  
Masaki Takimoto ◽  
Taku Hamada ◽  
Claude Messier

2020 ◽  
Vol 74 ◽  
pp. 109710 ◽  
Author(s):  
Anna Pintér ◽  
Zsófia Hevesi ◽  
Péter Zahola ◽  
Alán Alpár ◽  
János Hanics

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