scholarly journals Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states

Pain ◽  
2011 ◽  
Vol 152 (3) ◽  
pp. 649-655 ◽  
Author(s):  
Amin Boroujerdi ◽  
Jun Zeng ◽  
Kelli Sharp ◽  
Donghyun Kim ◽  
Oswald Steward ◽  
...  
EP Europace ◽  
2011 ◽  
Vol 14 (1) ◽  
pp. 146-147 ◽  
Author(s):  
M. Peyrol ◽  
P. Sbragia ◽  
J. A. Trigano ◽  
F. Paganelli

2010 ◽  
Vol 27 (9) ◽  
pp. 1697-1707 ◽  
Author(s):  
Julie Wieseler ◽  
Amanda L. Ellis ◽  
Andrew McFadden ◽  
Kimberley Brown ◽  
Charlotte Starnes ◽  
...  

Nature ◽  
1997 ◽  
Vol 386 (6624) ◽  
pp. 495-498 ◽  
Author(s):  
Neeraj Jain ◽  
Kenneth C. Catania ◽  
Jon H. Kaas

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chiaki Yamada ◽  
Aiko Maeda ◽  
Katsuyuki Matsushita ◽  
Shoko Nakayama ◽  
Kazuhiro Shirozu ◽  
...  

Abstract Background Patients with spinal cord injury (SCI) frequently complain of intractable pain that is resistant to conservative treatments. Here, we report the successful application of 1-kHz high-frequency spinal cord stimulation (SCS) in a patient with refractory neuropathic pain secondary to SCI. Case presentation A 69-year-old male diagnosed with SCI (C4 American Spinal Injury Association Impairment Scale A) presented with severe at-level bilateral upper extremity neuropathic pain. Temporary improvement in his symptoms with a nerve block implied peripheral component involvement. The patient received SCS, and though the tip of the leads could not reach the cervical vertebrae, a 1-kHz frequency stimulus relieved the intractable pain. Conclusions SCI-related symptoms may include peripheral components; SCS may have a considerable effect on intractable pain. Even when the SCS electrode lead cannot be positioned in the target area, 1-kHz high-frequency SCS may still produce positive effects.


Author(s):  
Andrew D. Gaudet ◽  
Laura K. Fonken ◽  
Monica T. Ayala ◽  
Steven F. Maier ◽  
Linda R. Watkins

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