Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain

2015 ◽  
Vol 130 ◽  
pp. 46-52 ◽  
Author(s):  
Yoshihiro Takahashi ◽  
Koji Hara ◽  
Yasunori Haranishi ◽  
Tadanori Terada ◽  
Goh Obara ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Intracerebroventricular Administration ◽  
Rat Models ◽  
Glycine Transporter ◽  
Glycine Transporter 2

The Antinociceptive Effect of Intrathecal Administration of Glycine Transporter-2 Inhibitor ALX1393 in a Rat Acute Pain Model

2010 ◽  
Vol 110 (2) ◽  
pp. 615-621 ◽  
Author(s):  
Yasunori Haranishi ◽  
Koji Hara ◽  
Tadanori Terada ◽  
Seiya Nakamura ◽  
Takeyoshi Sata
Keyword(s):  
Acute Pain ◽  
Antinociceptive Effect ◽  
Intrathecal Administration ◽  
Pain Model ◽  
Glycine Transporter ◽  
Glycine Transporter 2

scholarly journals Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, in a mouse model of neuropathic pain

2015 ◽  
Vol 127 (3) ◽  
pp. 377-381 ◽  
Author(s):  
Yu Omori ◽  
Mayumi Nakajima ◽  
Kazumi Nishimura ◽  
Eiki Takahashi ◽  
Tadamasa Arai ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Mouse Model ◽  
Analgesic Effect ◽  
Glycine Transporter ◽  
Glycine Transporter 2

The Antinociceptive Effect of the Asthma Drug Ibudilast in Rat Models of Peripheral and Central Neuropathic Pain

2012 ◽  
Vol 29 (3) ◽  
pp. 600-610 ◽  
Author(s):  
Aldric T. Hama ◽  
Alex Broadhead ◽  
Daniel S. Lorrain ◽  
Jacqueline Sagen
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Rat Models ◽  
Central Neuropathic Pain ◽  
Asthma Drug

Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain

Amino Acids ◽  
2011 ◽  
Vol 43 (1) ◽  
pp. 397-404 ◽  
Author(s):  
Koji Hara ◽  
Motohiro Nakamura ◽  
Yasunori Haranishi ◽  
Tadanori Terada ◽  
Kazunori Kataoka ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Intrathecal Administration ◽  
Rat Models

797 THE ANTINOCICEPTIVE EFFECT OF TRAMADOL PLUS DEXMEDETOMIDINE COMBINATION ON ACUTE AND NEUROPATHIC PAIN IN THE RAT MODELS

2006 ◽  
Vol 10 (S1) ◽  
pp. S207b-S207
Author(s):  
E. Guneli ◽  
N.U. Karabay-Yavasoglu ◽  
S. Apaydin ◽  
M. Uyar ◽  
M. Uyar
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Rat Models

scholarly journals The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Yan Dong ◽  
Chong-Yang Li ◽  
Xiao-Min Zhang ◽  
Ya-Nan Liu ◽  
Shuang Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Pain Threshold ◽  
Antinociceptive Effect ◽  
Galanin Receptor ◽  
Pain Model ◽  
Withdrawal Threshold ◽  
Neuropathic Pain Model ◽  
Galanin Receptors ◽  
Intact Rats

AbstractOur previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 in galanin-induced antinociceptive effect in NAc of neuropathic pain rats. The chronic constriction injury of sciatic nerve (CCI) was used to mimic neuropathic pain model. The hind paw withdrawal latency (HWL) to thermal stimulation and hind paw withdrawal threshold (HWT) to mechanical stimulation were measured as the indicators of pain threshold. The results showed that 14 and 28 days after CCI, the expression of GalR2 was up-regulated in bilateral NAc of rats, and intra-NAc injection of GalR2 antagonist M871 reversed galanin-induced increases in HWL and HWT of CCI rats. Furthermore, intra-NAc injection of GalR2 agonist M1145 induced increases in HWL and HWT at day 14 and day 28 after CCI, which could also be reversed by M871. Finally, we found that M1145-induced antinociceptive effect in NAc of CCI rats was stronger than that in intact rats. These results imply that the GalR2 is activated in the NAc from day 14 to day 28 after CCI and GalR2 is involved in the galanin-induced antinociceptive effect in NAc of CCI rats.

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