Effects of chronic l-DOPA administration on neurogenic and endothelium-dependent relaxation responses in rabbit corpus cavernosum

2016 ◽  
Vol 68 (5) ◽  
pp. 926-934 ◽  
Author(s):  
Şeniz Yıldırım ◽  
Gökçe Sevim Öztürk Fincan ◽  
Fatma İşli ◽  
Sevim Ercan ◽  
Yusuf Sarıoğlu
Keyword(s):  
Corpus Cavernosum ◽  
Rabbit Corpus Cavernosum ◽  
Relaxation Responses ◽  
Endothelium Dependent Relaxation

Resveratrol Protects and Restores Endothelium-Dependent Relaxation in Hypercholesterolemic Rabbit Corpus Cavernosum

2016 ◽  
Vol 13 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Nergiz Murat ◽  
Peyda Korhan ◽  
Onur Kizer ◽  
Sinem Evcim ◽  
Aykut Kefi ◽  
...  
Keyword(s):  
Corpus Cavernosum ◽  
Rabbit Corpus Cavernosum ◽  
Endothelium Dependent Relaxation

Depression induced by chronic stress leads to penile cavernosal dysfunction: protective effect of anti-TNF-α treatment

2018 ◽  
Vol 96 (9) ◽  
pp. 933-942 ◽  
Author(s):  
Tuğçe Demirtaş Şahin ◽  
Yusufhan Yazir ◽  
Tijen Utkan ◽  
Gulcin Gacar ◽  
Zehra Seda Halbutoğulları ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Corpus Cavernosum ◽  
No Synthase ◽  
Intercellular Adhesion Molecule ◽  
Mild Stress ◽  
Intercellular Adhesion Molecule 1 ◽  
Testosterone Levels ◽  
Tnf Α ◽  
Relaxation Responses ◽  
Endothelium Dependent Relaxation

Psychological stress may lead to erectile dysfunction (ED), and inflammation has been evaluated as a major contributing factor. The goal of this study was to investigate the effects of etanercept (ETN), an anti-tumor necrosis factor α (TNF-α) protein, on cavernosal function in the unpredictable chronic mild stress (UCMS) rat model of depression. Animals were divided into 4 groups: animals not exposed to UCMS, animals not exposed to UCMS and treated with ETN, animals exposed to UCMS, and animals treated with ETN while exposed to UCMS. UCMS significantly impaired the neurogenic and endothelium-dependent relaxation responses; reduced cavernosal endothelial nitric oxide (NO) synthase (eNOS) and neuronal NO synthase (nNOS) expressions; decreased testosterone levels; enhanced systemic levels of corticosterone, TNF-α, interleukin 1β (IL-1β), interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1); and also increased cavernosal levels of TNF-α, IL-1β, and IL-6 in rats. ETN administration restored NO-mediated neurogenic and endothelium-dependent relaxation responses of the corpus cavernosum, increased cavernosal eNOS and nNOS expressions, enhanced testosterone levels, and decreased corticosterone levels in UCMS-exposed rats. Also, systemic inflammatory markers and cavernosal proinflammatory cytokine levels were reduced by ETN. Our results demonstrate the role of TNF-α-mediated inflammation in the development of depression and ED in rats exposed to chronic stress.

The participation of adenosine receptors in the adenosine 5′-triphosphate-induced relaxation in the isolated rabbit corpus cavernosum penis

2007 ◽  
Vol 14 (8) ◽  
pp. 764-768 ◽  
Author(s):  
Kazuyoshi Kataoka ◽  
Katsuo Furukawa ◽  
Kohichi Nagao ◽  
Nobuhisa Ishii ◽  
Hiromichi Tsuru
Keyword(s):  
Adenosine Receptors ◽  
Corpus Cavernosum ◽  
Rabbit Corpus Cavernosum
Sign in / Sign up

Export Citation Format

Share Document