Pitolisant versus placebo for excessive daytime sleepiness in narcolepsy and obstructive sleep apnea: A meta-analysis from randomized controlled trials

2021 ◽  
Vol 167 ◽  
pp. 105522
Author(s):  
Jiahe Wang ◽  
Xiang Li ◽  
Siyuan Yang ◽  
Tianyi Wang ◽  
Zhongmou Xu ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Randomized Controlled Trials ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Obstructive Sleep

The effect of non-benzodiazepine sedative hypnotics on CPAP adherence in patients with OSA: a systematic review and meta-analysis

SLEEP ◽  
2021 ◽  
Author(s):  
Donghao Wang ◽  
Yongkang Tang ◽  
Yanghang Chen ◽  
Sun Zhang ◽  
Danjie Ma ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Cpap Adherence ◽  
Randomized Controlled ◽  
Obstructive Sleep ◽  
Sedative Hypnotics

Abstract Study objectives This meta-analysis aimed to explore the effect of non-benzodiazepine sedative hypnotics (NBSH) on continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA). Methods We conducted a systematic search through PubMed, Medline, the Cochrane Library, EMBASE, Scopus and ClinicalTrials (all searched from inception to 15 August 2020). Publications were limited to articles, clinical conferences and letters, including randomized controlled trials and retrospective studies. We used a random-effects model to calculate the odds ratio (OR) and mean difference (MD) with corresponding confidence interval (CI). Subgroup analyses were conducted to analyze the sources of heterogeneity. Results Eight studies fulfilled the inclusion and exclusion criteria for patients newly diagnosed with obstructive sleep apnea. Overall, the use of NBSH was associated with increased use of CPAP per night (MD = 0.62 h; 95% CI = 0.26-0.98) and use for more nights (MD = 12.08%; 95% CI = 5.27-18.88). When a study seriously affecting heterogeneity was removed, more patients adhered well with CPAP use (pooled OR = 2.48; 95% CI = 1.75-3.52) with good adherence defined as CPAP use for＞4 h/night on＞70% of nights. Among prescribed NBSHs, eszopiclone showed the most significant effect on CPAP adherence. Conclusion CPAP adherence may increase in OSA patients treated with non-benzodiazepine sedative hypnotics especially eszopiclone. The effect of zolpidem and zaleplon on CPAP adherence requires further investigation by larger scale, randomized, controlled trials.

Effects of Modafinil and Armodafinil in Patients With Obstructive Sleep Apnea: A Meta-analysis of Randomized Controlled Trials

2016 ◽  
Vol 38 (4) ◽  
pp. 874-888 ◽  
Author(s):  
Yi-Chun Kuan ◽  
Dean Wu ◽  
Kuang-Wei Huang ◽  
Nai-Fang Chi ◽  
Chaur-Jong Hu ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Obstructive Sleep

Cognitive Effects of Treating Obstructive Sleep Apnea: A Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 75 (3) ◽  
pp. 705-715
Author(s):  
Mei-Ling Wang ◽  
Chong Wang ◽  
Miao Tuo ◽  
Yang Yu ◽  
Lin Wang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Cognitive Effects ◽  
Randomized Controlled ◽  
Obstructive Sleep
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