Poster 176 Efficacy of Duloxetine in Patients With Chronic Low Back Pain Who Used Concomitant Nonsteroidal Anti-inflammatory Drugs: A Pooled Analysis of 2 Trials

PM&R ◽  
2011 ◽  
Vol 3 ◽  
pp. S230-S231
Author(s):  
Vladimir Skljarevski ◽  
Jonna Ahl ◽  
Peng Liu ◽  
James Martinez ◽  
Zhuyu Zhang
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Vladimir Skljarevski ◽  
Peng Liu ◽  
Shuyu Zhang ◽  
Jonna Ahl ◽  
James M. Martinez

This subgroup analysis assessed the efficacy of duloxetine in patients with chronic low back pain (CLBP) who did or did not use concomitant nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen (APAP). Data were pooled from two 13-week randomized trials in patients with CLBP who were stratified according to NSAID/APAP use at baseline: duloxetine NSAID/APAP user (), placebo NSAID/APAP user (), duloxetine NSAID/APAP nonuser (), and placebo NSAID/APAP nonuser (). NSAID/APAP users were those patients who took NSAID/APAP for at least 14 days per month during 3 months prior to study entry. An analysis of covariance model that included therapy, study, baseline NSAID/APAP use (yes/no), and therapy-by-NSAID/APAP subgroup interaction was used to assess the efficacy. The treatment-by-NSAID/APAP use interaction was not statistically significant () suggesting no substantial evidence of differential efficacy for duloxetine over placebo on pain reduction or improvement in physical function between concomitant NSAID/APAP users and non-users.


Author(s):  
Wendy TM Enthoven ◽  
Pepijn DDM Roelofs ◽  
Richard A Deyo ◽  
Maurits W van Tulder ◽  
Bart W Koes

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Marian Majchrzycki ◽  
Piotr Kocur ◽  
Tomasz Kotwicki

Objective. To investigate whether chronic low back pain therapy with deep tissue massage (DTM) gives similar results to combined therapy consisting of DTM and non-steroid anti-inflammatory drugs (NSAID).Design. Prospective controlled randomized single blinded trial.Settings. Ambulatory care of rehabilitation.Participants. 59 patients, age 51.8 ± 9.0 years, with chronic low back pain.Interventions. 2 weeks of DTM in the treatment group (TG) versus 2 weeks of DTM combined with NSAID in the control group (CG).Main Outcome Measures. Visual analogue scale, Oswestry disability index (ODI), and Roland-Morris questionnaire (RM).Results. In both the TG and the CG, a significant pain reduction and function improvement were observed. VAS decreased from 58.3 ± 18.2 to 42.2 ± 21.1 (TG) and from 51.8 ± 18.8 to 30.6 ± 21.9 (CG). RM value decreased from 9.8 ± 5.1 to 6.4 ± 4.4 (TG), and from 9.3 ± 5.5 to 6.1 ± 4.6 (CG). ODI value decreased from 29.2 ± 17.3 to 21.4 ± 15.1 (TG) and from 21.4 ± 9.4 to 16.6 ± 9.4 (CG). All pre-post-treatment differences were significant; however, there was no significant difference between the TG and the CG.Conclusion. DTM had a positive effect on reducing pain in patients with chronic low back pain. Concurrent use of DTM and NSAID contributed to low back pain reduction in a similar degree that the DTM did.


2013 ◽  
Vol 66 (12) ◽  
pp. 1397-1404 ◽  
Author(s):  
Manuela L. Ferreira ◽  
Robert D. Herbert ◽  
Paulo H. Ferreira ◽  
Jane Latimer ◽  
Raymond W. Ostelo ◽  
...  

Author(s):  
Pepijn DDM Roelofs ◽  
Rick A Deyo ◽  
Bart W Koes ◽  
Rob JPM Scholten ◽  
Maurits W van Tulder

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